FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062670892> ?p ?o ?g. }

• W2062670892 endingPage "2027" @default.
• W2062670892 startingPage "2018" @default.
• W2062670892 abstract "Several uncontrolled studies report improvement in lung function, gas exchange, and exercise capacity after bilateral lung volume reduction surgery (LVRS). We recruited 200 patients with severe chronic obstructive pulmonary disease (COPD) for a prospective randomized trial of pulmonary rehabilitation versus bilateral LVRS with stapling resection of 20 to 40% of each lung. Pulmonary function tests, gas exchange, 6-min walk distance, and symptom-limited maximal exercise testing were done in all patients at baseline and after 8 wk of rehabilitation. Patients were then randomized to either 3 additional months of rehabilitation or LVRS. Thirty-seven patients met study criteria and were enrolled into the trial. Eighteen patients were in the medical arm; 15 of 18 patients completed 3 mo of additional pulmonary rehabilitation. Thirty-two patients underwent LVRS (19 in the surgical arm, 13 crossover from the medical arm). After 8 wk of pulmonary rehabilitation, pulmonary function tests remained unchanged compared with baseline data. However, there was a trend toward a higher 6-min walk distance (285 ± 96 versus 269 ± 91 m, p = 0.14) and total exercise time on maximal exercise test was significantly longer compared with baseline values (7.4 ± 2.1 versus 5.8 ± 1.7 min, p < 0.001). In 15 patients who completed 3 mo of additional rehabilitation, there was a trend to a higher maximal oxygen consumption (V˙ o 2max) (13.3 ± 3.0 versus 12.6 ± 3.3, p < 0.08). In contrast, at 3 mo post-LVRS, FVC (2.79 ± 0.59 versus 2.36 ± 0.55 L, p < 0.001) and FEV1 (0.85 ± 0.3 versus 0.65 ± 0.16 L, p < 0.005) increased whereas TLC (6.53 ± 1.3 versus 7.65 ± 2.1 L, p < 0.001) and residual volume (RV) (3.7 ± 1.2 versus 4.9 ± 1.1 L, p < 0.001) decreased when compared with 8 wk postrehabilitation data. In addition, PaCO2 decreased significantly 3 mo post-LVRS compared with 8 wk postrehabilitation. Six-minute walk distance (6MWD), total exercise time, and V˙ o 2max were higher after LVRS but did not reach statistical significance. However, when 13 patients who crossed over from the medical to the surgical arm were included in the analysis, the increases in 6MWD (337 ± 99 versus 282 ± 100 m, p < 0.001) and V˙ o 2max (13.8 ± 4 versus 12.0 ± 3 ml/kg/min, p < 0.01) 3 mo post-LVRS were highly significant when compared with postrehabilitation data. The Sickness Impact Profile (SIP), a generalized measure of quality of life (QOL), was significantly improved after 8 wk of rehabilitation and was maintained after 3 mo of additional rehabilitation. A further improvement in QOL was observed 3 mo after LVRS compared with the initial improvement gained after 8 wk of rehabilitation. There were 3 (9.4%) postoperative deaths, and one patient died before surgery (2.7%). We conclude that bilateral LVRS, in addition to pulmonary rehabilitation, improves static lung function, gas exchange, and QOL compared with pulmonary rehabilitation alone. Further studies need to evaluate the risks, benefits, and durability of LVRS over time. Criner GJ, Cordova FC, Furukawa S, Kuzma AM, Travaline JM, Leyenson V, O'Brien GM. Prospective randomized trial comparing bilateral lung volume reduction surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease." @default.
• W2062670892 created "2016-06-24" @default.
• W2062670892 creator A5004989239 @default.
• W2062670892 creator A5009003396 @default.
• W2062670892 creator A5033691821 @default.
• W2062670892 creator A5051431522 @default.
• W2062670892 creator A5052196846 @default.
• W2062670892 creator A5073407819 @default.
• W2062670892 creator A5088605057 @default.
• W2062670892 date "1999-12-01" @default.
• W2062670892 modified "2023-10-15" @default.
• W2062670892 title "Prospective Randomized Trial Comparing Bilateral Lung Volume Reduction Surgery to Pulmonary Rehabilitation in Severe Chronic Obstructive Pulmonary Disease" @default.
• W2062670892 cites W1966190365 @default.
• W2062670892 cites W1968927833 @default.
• W2062670892 cites W1969665190 @default.
• W2062670892 cites W1974611203 @default.
• W2062670892 cites W1975285483 @default.
• W2062670892 cites W1976379774 @default.
• W2062670892 cites W1982281674 @default.
• W2062670892 cites W1991264726 @default.
• W2062670892 cites W2012261995 @default.
• W2062670892 cites W2019616711 @default.
• W2062670892 cites W2020098896 @default.
• W2062670892 cites W2022889830 @default.
• W2062670892 cites W2026217381 @default.
• W2062670892 cites W2027954146 @default.
• W2062670892 cites W2041369332 @default.
• W2062670892 cites W2041532866 @default.
• W2062670892 cites W2043862418 @default.
• W2062670892 cites W2044177685 @default.
• W2062670892 cites W2073355716 @default.
• W2062670892 cites W2078669720 @default.
• W2062670892 cites W2082410143 @default.
• W2062670892 cites W2093017323 @default.
• W2062670892 cites W2113163333 @default.
• W2062670892 cites W2116525742 @default.
• W2062670892 cites W2118994658 @default.
• W2062670892 cites W2119348698 @default.
• W2062670892 cites W2147404147 @default.
• W2062670892 cites W2151231052 @default.
• W2062670892 cites W2154231864 @default.
• W2062670892 cites W2262523178 @default.
• W2062670892 cites W4230665126 @default.
• W2062670892 cites W4245089651 @default.
• W2062670892 cites W4249200669 @default.
• W2062670892 doi "https://doi.org/10.1164/ajrccm.160.6.9902117" @default.
• W2062670892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10588623" @default.
• W2062670892 hasPublicationYear "1999" @default.
• W2062670892 type Work @default.
• W2062670892 sameAs 2062670892 @default.
• W2062670892 citedByCount "259" @default.
• W2062670892 countsByYear W20626708922012 @default.
• W2062670892 countsByYear W20626708922013 @default.
• W2062670892 countsByYear W20626708922014 @default.
• W2062670892 countsByYear W20626708922015 @default.
• W2062670892 countsByYear W20626708922016 @default.
• W2062670892 countsByYear W20626708922017 @default.
• W2062670892 countsByYear W20626708922018 @default.
• W2062670892 countsByYear W20626708922019 @default.
• W2062670892 countsByYear W20626708922020 @default.
• W2062670892 countsByYear W20626708922021 @default.
• W2062670892 countsByYear W20626708922022 @default.
• W2062670892 crossrefType "journal-article" @default.
• W2062670892 hasAuthorship W2062670892A5004989239 @default.
• W2062670892 hasAuthorship W2062670892A5009003396 @default.
• W2062670892 hasAuthorship W2062670892A5033691821 @default.
• W2062670892 hasAuthorship W2062670892A5051431522 @default.
• W2062670892 hasAuthorship W2062670892A5052196846 @default.
• W2062670892 hasAuthorship W2062670892A5073407819 @default.
• W2062670892 hasAuthorship W2062670892A5088605057 @default.
• W2062670892 hasConcept C126322002 @default.
• W2062670892 hasConcept C141071460 @default.
• W2062670892 hasConcept C164705383 @default.
• W2062670892 hasConcept C168563851 @default.
• W2062670892 hasConcept C1862650 @default.
• W2062670892 hasConcept C188816634 @default.
• W2062670892 hasConcept C27101514 @default.
• W2062670892 hasConcept C2775982285 @default.
• W2062670892 hasConcept C2776178081 @default.
• W2062670892 hasConcept C2776780178 @default.
• W2062670892 hasConcept C2777714996 @default.
• W2062670892 hasConcept C2778818304 @default.
• W2062670892 hasConcept C2780779891 @default.
• W2062670892 hasConcept C71924100 @default.
• W2062670892 hasConcept C75603125 @default.
• W2062670892 hasConceptScore W2062670892C126322002 @default.
• W2062670892 hasConceptScore W2062670892C141071460 @default.
• W2062670892 hasConceptScore W2062670892C164705383 @default.
• W2062670892 hasConceptScore W2062670892C168563851 @default.
• W2062670892 hasConceptScore W2062670892C1862650 @default.
• W2062670892 hasConceptScore W2062670892C188816634 @default.
• W2062670892 hasConceptScore W2062670892C27101514 @default.
• W2062670892 hasConceptScore W2062670892C2775982285 @default.
• W2062670892 hasConceptScore W2062670892C2776178081 @default.
• W2062670892 hasConceptScore W2062670892C2776780178 @default.
• W2062670892 hasConceptScore W2062670892C2777714996 @default.
• W2062670892 hasConceptScore W2062670892C2778818304 @default.
• W2062670892 hasConceptScore W2062670892C2780779891 @default.

• next