Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062679162> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2062679162 endingPage "50" @default.
- W2062679162 startingPage "47" @default.
- W2062679162 abstract "Renin inhibition has been evaluated for a new class of fluorinated ketones, true analogues of peptides that have been retroinverted at the C-terminal position. The readily formed hydrate of the ketone is proposed to mimic the tetrahedral intermediate that occurs during the enzyme-catalyzed hydrolysis of amide linkage. From this series of compounds it appears that the number of reverted amide bonds is crucial in terms of activity. Furthermore, a shortening of the C-terminal part of our peptide analogues and the replacement of the leucine residue in P1 by a cyclohexylalanine leads to the tripeptide analogue 12 a potent renin inhibitor (IC50 = 3.5 x 10(-9) M)." @default.
- W2062679162 created "2016-06-24" @default.
- W2062679162 creator A5003458553 @default.
- W2062679162 creator A5024617331 @default.
- W2062679162 creator A5028814613 @default.
- W2062679162 creator A5073773810 @default.
- W2062679162 creator A5083032040 @default.
- W2062679162 date "1989-05-22" @default.
- W2062679162 modified "2023-09-26" @default.
- W2062679162 title "New fluoroketones as human renin inhibitors" @default.
- W2062679162 cites W1980744726 @default.
- W2062679162 cites W1983316387 @default.
- W2062679162 cites W1989091228 @default.
- W2062679162 cites W2001126523 @default.
- W2062679162 cites W2017607746 @default.
- W2062679162 cites W2020810067 @default.
- W2062679162 cites W2027307844 @default.
- W2062679162 cites W2027610936 @default.
- W2062679162 cites W2035055307 @default.
- W2062679162 cites W2035852030 @default.
- W2062679162 cites W2040701197 @default.
- W2062679162 cites W2069401173 @default.
- W2062679162 cites W2074593863 @default.
- W2062679162 cites W2077196279 @default.
- W2062679162 cites W2128205895 @default.
- W2062679162 cites W4235832805 @default.
- W2062679162 doi "https://doi.org/10.1016/0014-5793(89)80012-2" @default.
- W2062679162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2656298" @default.
- W2062679162 hasPublicationYear "1989" @default.
- W2062679162 type Work @default.
- W2062679162 sameAs 2062679162 @default.
- W2062679162 citedByCount "12" @default.
- W2062679162 countsByYear W20626791622015 @default.
- W2062679162 crossrefType "journal-article" @default.
- W2062679162 hasAuthorship W2062679162A5003458553 @default.
- W2062679162 hasAuthorship W2062679162A5024617331 @default.
- W2062679162 hasAuthorship W2062679162A5028814613 @default.
- W2062679162 hasAuthorship W2062679162A5073773810 @default.
- W2062679162 hasAuthorship W2062679162A5083032040 @default.
- W2062679162 hasBestOaLocation W20626791621 @default.
- W2062679162 hasConcept C134018914 @default.
- W2062679162 hasConcept C167392928 @default.
- W2062679162 hasConcept C178790620 @default.
- W2062679162 hasConcept C181199279 @default.
- W2062679162 hasConcept C185592680 @default.
- W2062679162 hasConcept C198710026 @default.
- W2062679162 hasConcept C2777425892 @default.
- W2062679162 hasConcept C2777738585 @default.
- W2062679162 hasConcept C2778439535 @default.
- W2062679162 hasConcept C2779138802 @default.
- W2062679162 hasConcept C2779281246 @default.
- W2062679162 hasConcept C2781338088 @default.
- W2062679162 hasConcept C31684184 @default.
- W2062679162 hasConcept C55493867 @default.
- W2062679162 hasConcept C71240020 @default.
- W2062679162 hasConcept C84393581 @default.
- W2062679162 hasConcept C86803240 @default.
- W2062679162 hasConcept C94412978 @default.
- W2062679162 hasConceptScore W2062679162C134018914 @default.
- W2062679162 hasConceptScore W2062679162C167392928 @default.
- W2062679162 hasConceptScore W2062679162C178790620 @default.
- W2062679162 hasConceptScore W2062679162C181199279 @default.
- W2062679162 hasConceptScore W2062679162C185592680 @default.
- W2062679162 hasConceptScore W2062679162C198710026 @default.
- W2062679162 hasConceptScore W2062679162C2777425892 @default.
- W2062679162 hasConceptScore W2062679162C2777738585 @default.
- W2062679162 hasConceptScore W2062679162C2778439535 @default.
- W2062679162 hasConceptScore W2062679162C2779138802 @default.
- W2062679162 hasConceptScore W2062679162C2779281246 @default.
- W2062679162 hasConceptScore W2062679162C2781338088 @default.
- W2062679162 hasConceptScore W2062679162C31684184 @default.
- W2062679162 hasConceptScore W2062679162C55493867 @default.
- W2062679162 hasConceptScore W2062679162C71240020 @default.
- W2062679162 hasConceptScore W2062679162C84393581 @default.
- W2062679162 hasConceptScore W2062679162C86803240 @default.
- W2062679162 hasConceptScore W2062679162C94412978 @default.
- W2062679162 hasIssue "1" @default.
- W2062679162 hasLocation W20626791621 @default.
- W2062679162 hasLocation W20626791622 @default.
- W2062679162 hasOpenAccess W2062679162 @default.
- W2062679162 hasPrimaryLocation W20626791621 @default.
- W2062679162 hasRelatedWork W1442915068 @default.
- W2062679162 hasRelatedWork W2026882403 @default.
- W2062679162 hasRelatedWork W2042804914 @default.
- W2062679162 hasRelatedWork W2062679162 @default.
- W2062679162 hasRelatedWork W2132020991 @default.
- W2062679162 hasRelatedWork W2146987488 @default.
- W2062679162 hasRelatedWork W2170509739 @default.
- W2062679162 hasRelatedWork W2316617565 @default.
- W2062679162 hasRelatedWork W2324561943 @default.
- W2062679162 hasRelatedWork W3027146158 @default.
- W2062679162 hasVolume "249" @default.
- W2062679162 isParatext "false" @default.
- W2062679162 isRetracted "false" @default.
- W2062679162 magId "2062679162" @default.
- W2062679162 workType "article" @default.