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- W2062699336 endingPage "538" @default.
- W2062699336 startingPage "525" @default.
- W2062699336 abstract "Combinatorial chemistry and parallel synthesis are important and regularly applied tools for lead identification and optimisation, although they are often accompanied by challenges related to the efficiency of library synthesis and the purity of the compound library. In the last decade, novel means of lead discovery approaches have been investigated where the biological target is actively involved in the synthesis of its own inhibitory compound. These fragment-based approaches, also termed target-guided synthesis (TGS), show great promise in lead discovery applications by combining the synthesis and screening of libraries of low molecular weight compounds in a single step. Of all the TGS methods, the kinetically controlled variant is the least well known, but it has the potential to emerge as a reliable lead discovery method. The kinetically controlled TGS approach, termed in situ click chemistry, is discussed in this article." @default.
- W2062699336 created "2016-06-24" @default.
- W2062699336 creator A5018717493 @default.
- W2062699336 creator A5077401880 @default.
- W2062699336 date "2006-11-01" @default.
- W2062699336 modified "2023-10-15" @default.
- W2062699336 title "<i>In situ</i>click chemistry: a powerful means for lead discovery" @default.
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