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- W2062706497 abstract "Human T lymphocytes bearing the cell surface antigen T4 are functionally heterogeneous, exerting helper/inducer, suppressor-inducer, suppressor-effector, and cytotoxic activities. Other cell surface antigens with a more restricted expression may help separate T4+ lymphocytes into functionally distinct subsets. This report describes the regulatory functions of T4+ lymphocytes fractionated by the monoclonal antibody 59, which detects a cell surface antigen present on 50–60% of T4+ lymphocytes. The results indicate that both 59+ and 59− T4 subsets contain helper/inducer and suppressor-inducer cells. Suppressor-effector activity, however, is found predominantly within the 59+ T4 subset. The 59 antibody thus identifies the suppressor-effector subset of T4+ lymphocytes, although it does not distinguish between T4+ cells with or without helper/inducer and suppressor-inducer functions." @default.
- W2062706497 created "2016-06-24" @default.
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- W2062706497 date "1987-06-01" @default.
- W2062706497 modified "2023-10-18" @default.
- W2062706497 title "Functional studies of T4+ lymphocyte subsets distinguished by the monoclonal antibody 59: Suppressor-effector T4+ lymphocytes derive from the 59+ subset" @default.
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- W2062706497 doi "https://doi.org/10.1016/0008-8749(87)90277-2" @default.
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