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• W2062733479 abstract "Ribonucleic acid extracts of lymphoid cells from immune hosts were used to transfer in vivo and in vitro cell-mediated immune reactivity to a variety of antigens. The in vivo immune responses transferred by RNA included the delayed cutaneous hypersensitivity reaction to fungal and chemically-defined antigens and the tumor-rejection reaction to guinea pig hepatoma antigens. The in vitro immune responses transferred by RNA included macrophage migration inhibition by fungal, chemically-defined, and tumor antigens. The transfer activity of RNA preparations was contained in the 8 s to 18 s species of RNA and was sensitive to RNAse but not to DNase or trypsin. Antigen was not detectable in the RNA preparations and appeared to have no role in the transfer activity. Syngeneic, allogeneic, or xenogeneic sources of RNA could transfer immune reactivity. In each system tested, the transfer of cell-mediated reactivity by RNA was specific for the antigen used to sensitize the RNA donor. The potential use of RNA-mediated transfer of immunity is discussed." @default.
• W2062733479 created "2016-06-24" @default.
• W2062733479 creator A5015904772 @default.
• W2062733479 creator A5023537939 @default.
• W2062733479 date "1979-05-01" @default.
• W2062733479 modified "2023-09-27" @default.
• W2062733479 title "Some perspectives on the transfer of cell-mediated immunity by immune-RNA" @default.
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• W2062733479 doi "https://doi.org/10.1007/bf00211138" @default.
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