FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062743722> ?p ?o ?g. }

• W2062743722 endingPage "2025" @default.
• W2062743722 startingPage "2017" @default.
• W2062743722 abstract "Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity are both associated with dopaminergic neuron death in the substantia nigra. Although a variety of evidence has shown that degenerative cells have apoptotic features, the role of apoptosis in disease pathology remains controversial. The 1-methyl-4-phenylpyridinium ion (MPP+), a metabolite of MPTP, was recently shown to alter the expression of proteins involved in translational control. The initiation step of translational control is regulated by a cascade of phosphorylation affecting proteins of the antiapoptotic way controlled by mammalian target of rapamycin (mTOR) and of the proapoptotic way controlled by double-stranded RNA protein–dependent kinase (PKR). A study showed that MPP+ induced an increase in eIF2α phosphorylation, leading to inhibition of protein synthesis. The aims of our study were: (1) to assess the effects of MPP+ toxicity on molecular factors of PKR and mTOR signaling pathways in murine neuroblastoma cells, and (2) to examine the ability of VIP and PACAP peptides to counteract the MPP+ toxicity. Our findings showed that MPP+ induced phosphorylation of eIF2α and significantly reduced the expression of phosphorylated mTOR, p70S6K, eIF4E, and 4E-BP1, suggesting its toxicity in controlling protein synthesis. Furthermore, the VIP peptide had no effect on either the PKR or the mTOR signaling pathway. On the contrary, the PACAP 27 neuropeptide prevented MPP+-induced eIF2α phosphorylation and blocked MPP+ toxicity in molecular factors of the mTOR pathway. And last, PACAP 27 seemed to protect Neuro-2a cells from the apoptotic process as assessed by the decreased nuclear condensation after DAPI staining. These results could open new paths of research of PACAP in PD. © 2007 Wiley-Liss, Inc." @default.
• W2062743722 created "2016-06-24" @default.
• W2062743722 creator A5012699429 @default.
• W2062743722 creator A5021186878 @default.
• W2062743722 creator A5039250629 @default.
• W2062743722 creator A5040511094 @default.
• W2062743722 creator A5068289228 @default.
• W2062743722 creator A5073015509 @default.
• W2062743722 creator A5075822619 @default.
• W2062743722 creator A5082796650 @default.
• W2062743722 date "2007-07-01" @default.
• W2062743722 modified "2023-10-18" @default.
• W2062743722 title "Neuroprotective effects of pituitary adenylate cyclase–activating polypeptide (PACAP) in MPP+-induced alteration of translational control in Neuro-2a neuroblastoma cells" @default.
• W2062743722 cites W152246401 @default.
• W2062743722 cites W1527707083 @default.
• W2062743722 cites W1587891756 @default.
• W2062743722 cites W1826988851 @default.
• W2062743722 cites W1934976150 @default.
• W2062743722 cites W1963723155 @default.
• W2062743722 cites W1974034152 @default.
• W2062743722 cites W1978262065 @default.
• W2062743722 cites W1985046929 @default.
• W2062743722 cites W1985266809 @default.
• W2062743722 cites W1989405078 @default.
• W2062743722 cites W1990275580 @default.
• W2062743722 cites W1993753481 @default.
• W2062743722 cites W1995607585 @default.
• W2062743722 cites W1995790354 @default.
• W2062743722 cites W1995868640 @default.
• W2062743722 cites W2002171978 @default.
• W2062743722 cites W2013806485 @default.
• W2062743722 cites W2014444130 @default.
• W2062743722 cites W2016654953 @default.
• W2062743722 cites W2018869671 @default.
• W2062743722 cites W2022797477 @default.
• W2062743722 cites W2022969546 @default.
• W2062743722 cites W2028563627 @default.
• W2062743722 cites W2029308011 @default.
• W2062743722 cites W2030019992 @default.
• W2062743722 cites W2032350393 @default.
• W2062743722 cites W2033774852 @default.
• W2062743722 cites W2037809197 @default.
• W2062743722 cites W2039578759 @default.
• W2062743722 cites W2047126558 @default.
• W2062743722 cites W2055959843 @default.
• W2062743722 cites W2058741571 @default.
• W2062743722 cites W2066649043 @default.
• W2062743722 cites W2069316268 @default.
• W2062743722 cites W2071293788 @default.
• W2062743722 cites W2072786295 @default.
• W2062743722 cites W2077580603 @default.
• W2062743722 cites W2080570756 @default.
• W2062743722 cites W2085133199 @default.
• W2062743722 cites W2086939601 @default.
• W2062743722 cites W2090476662 @default.
• W2062743722 cites W2091404872 @default.
• W2062743722 cites W2092393699 @default.
• W2062743722 cites W2119006335 @default.
• W2062743722 cites W2136632189 @default.
• W2062743722 cites W2152693222 @default.
• W2062743722 cites W2157497892 @default.
• W2062743722 cites W2158662449 @default.
• W2062743722 cites W2163382569 @default.
• W2062743722 cites W2465001371 @default.
• W2062743722 cites W3023167551 @default.
• W2062743722 cites W4243246029 @default.
• W2062743722 doi "https://doi.org/10.1002/jnr.21318" @default.
• W2062743722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17492795" @default.
• W2062743722 hasPublicationYear "2007" @default.
• W2062743722 type Work @default.
• W2062743722 sameAs 2062743722 @default.
• W2062743722 citedByCount "41" @default.
• W2062743722 countsByYear W20627437222012 @default.
• W2062743722 countsByYear W20627437222013 @default.
• W2062743722 countsByYear W20627437222014 @default.
• W2062743722 countsByYear W20627437222016 @default.
• W2062743722 countsByYear W20627437222017 @default.
• W2062743722 countsByYear W20627437222018 @default.
• W2062743722 countsByYear W20627437222019 @default.
• W2062743722 countsByYear W20627437222022 @default.
• W2062743722 countsByYear W20627437222023 @default.
• W2062743722 crossrefType "journal-article" @default.
• W2062743722 hasAuthorship W2062743722A5012699429 @default.
• W2062743722 hasAuthorship W2062743722A5021186878 @default.
• W2062743722 hasAuthorship W2062743722A5039250629 @default.
• W2062743722 hasAuthorship W2062743722A5040511094 @default.
• W2062743722 hasAuthorship W2062743722A5068289228 @default.
• W2062743722 hasAuthorship W2062743722A5073015509 @default.
• W2062743722 hasAuthorship W2062743722A5075822619 @default.
• W2062743722 hasAuthorship W2062743722A5082796650 @default.
• W2062743722 hasConcept C11960822 @default.
• W2062743722 hasConcept C134018914 @default.
• W2062743722 hasConcept C137183658 @default.
• W2062743722 hasConcept C25498285 @default.
• W2062743722 hasConcept C2778674702 @default.
• W2062743722 hasConcept C2780938664 @default.
• W2062743722 hasConcept C513476851 @default.
• W2062743722 hasConcept C62478195 @default.

• next