Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062745388> ?p ?o ?g. }
- W2062745388 endingPage "115" @default.
- W2062745388 startingPage "105" @default.
- W2062745388 abstract "This research aimed to develop in vitro methods to assess hazard of canine food ingredients. Canine hepatocytes were harvested and cell viability of clove-leaf oil (CLO), eugenol (EUG), lemongrass oil (LGO), guanosine monophosphate (GMP), inosine monophosphate (IMP), sorbose, ginger-root extract (GRE), cinnamon-bark oil (CBO), cinnamaldehyde (CINA), thymol oil (TO), thymol (THYM), and citric acid were assessed with positive controls: acetaminophen (APAP), aflatoxin B1 and xylitol. Molecular Toxicology PathwayFinder array (MTPF) analyzed toxicity mechanisms for LGO. LC50 for APAP was similar among human (3.45), rat (2.35), dog (4.26 mg/ml). Aflatoxin B1 had an LC50 of 4.43 (human), 5.78 (rat) and 6.05 (dog) µg/ml; xylitol did not decrease viability. LC50 of CLO (0.185 ± 0.075(SD)), EUG (0.165 ± 0.112), LGO (0.220 ± 0.012), GRE (1.54 ± 0.31) mg/ml; GMP (166.03 ± 41.83), GMP + IMP (208.67 ± 15.27) mM; CBO (0.08 ± 0.03), CINA (0.11 ± 0.01), TO (0.21 ± 0.03), THYM (0.05 ± 0.01), citric acid (1.58 ± 0.08) mg/ml, while sorbose was non-toxic. LGO induced upregulation of 16 and down-regulation of 24 genes, which CYP and heat shock most affected. These results suggest that in vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function." @default.
- W2062745388 created "2016-06-24" @default.
- W2062745388 creator A5010469020 @default.
- W2062745388 creator A5033950980 @default.
- W2062745388 creator A5038299644 @default.
- W2062745388 creator A5042809815 @default.
- W2062745388 creator A5058798862 @default.
- W2062745388 date "2015-04-01" @default.
- W2062745388 modified "2023-10-18" @default.
- W2062745388 title "Safety assessment of potential food ingredients in canine hepatocytes" @default.
- W2062745388 cites W1538291123 @default.
- W2062745388 cites W1969952966 @default.
- W2062745388 cites W1977292087 @default.
- W2062745388 cites W1977895641 @default.
- W2062745388 cites W1987650921 @default.
- W2062745388 cites W1987908785 @default.
- W2062745388 cites W1992333338 @default.
- W2062745388 cites W1995139611 @default.
- W2062745388 cites W1996363253 @default.
- W2062745388 cites W2000274938 @default.
- W2062745388 cites W2001719540 @default.
- W2062745388 cites W2003873847 @default.
- W2062745388 cites W2006120055 @default.
- W2062745388 cites W2006262882 @default.
- W2062745388 cites W2016575086 @default.
- W2062745388 cites W2032226527 @default.
- W2062745388 cites W2039121984 @default.
- W2062745388 cites W2041371533 @default.
- W2062745388 cites W2043560983 @default.
- W2062745388 cites W2046156456 @default.
- W2062745388 cites W2053836644 @default.
- W2062745388 cites W2062243771 @default.
- W2062745388 cites W2067916376 @default.
- W2062745388 cites W2071618232 @default.
- W2062745388 cites W2072556573 @default.
- W2062745388 cites W2072849164 @default.
- W2062745388 cites W2076817288 @default.
- W2062745388 cites W2079894653 @default.
- W2062745388 cites W2082357482 @default.
- W2062745388 cites W2085897097 @default.
- W2062745388 cites W2089240944 @default.
- W2062745388 cites W2095212217 @default.
- W2062745388 cites W2095441839 @default.
- W2062745388 cites W2110346321 @default.
- W2062745388 cites W2116553339 @default.
- W2062745388 cites W2117961602 @default.
- W2062745388 cites W2121865715 @default.
- W2062745388 cites W2123298111 @default.
- W2062745388 cites W2125500559 @default.
- W2062745388 cites W2136475768 @default.
- W2062745388 cites W2139313616 @default.
- W2062745388 cites W2143126819 @default.
- W2062745388 cites W2153284241 @default.
- W2062745388 cites W2153522951 @default.
- W2062745388 cites W2169548777 @default.
- W2062745388 cites W2169730190 @default.
- W2062745388 cites W2296911202 @default.
- W2062745388 cites W2314335495 @default.
- W2062745388 cites W2527082732 @default.
- W2062745388 doi "https://doi.org/10.1016/j.fct.2015.02.003" @default.
- W2062745388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25660481" @default.
- W2062745388 hasPublicationYear "2015" @default.
- W2062745388 type Work @default.
- W2062745388 sameAs 2062745388 @default.
- W2062745388 citedByCount "8" @default.
- W2062745388 countsByYear W20627453882015 @default.
- W2062745388 countsByYear W20627453882016 @default.
- W2062745388 countsByYear W20627453882020 @default.
- W2062745388 countsByYear W20627453882021 @default.
- W2062745388 countsByYear W20627453882023 @default.
- W2062745388 crossrefType "journal-article" @default.
- W2062745388 hasAuthorship W2062745388A5010469020 @default.
- W2062745388 hasAuthorship W2062745388A5033950980 @default.
- W2062745388 hasAuthorship W2062745388A5038299644 @default.
- W2062745388 hasAuthorship W2062745388A5042809815 @default.
- W2062745388 hasAuthorship W2062745388A5058798862 @default.
- W2062745388 hasConcept C178790620 @default.
- W2062745388 hasConcept C185592680 @default.
- W2062745388 hasConcept C2777278459 @default.
- W2062745388 hasConcept C2780470866 @default.
- W2062745388 hasConcept C2780642067 @default.
- W2062745388 hasConcept C31903555 @default.
- W2062745388 hasConcept C40758303 @default.
- W2062745388 hasConcept C55493867 @default.
- W2062745388 hasConcept C86803240 @default.
- W2062745388 hasConcept C98274493 @default.
- W2062745388 hasConceptScore W2062745388C178790620 @default.
- W2062745388 hasConceptScore W2062745388C185592680 @default.
- W2062745388 hasConceptScore W2062745388C2777278459 @default.
- W2062745388 hasConceptScore W2062745388C2780470866 @default.
- W2062745388 hasConceptScore W2062745388C2780642067 @default.
- W2062745388 hasConceptScore W2062745388C31903555 @default.
- W2062745388 hasConceptScore W2062745388C40758303 @default.
- W2062745388 hasConceptScore W2062745388C55493867 @default.
- W2062745388 hasConceptScore W2062745388C86803240 @default.
- W2062745388 hasConceptScore W2062745388C98274493 @default.
- W2062745388 hasFunder F4320309633 @default.
- W2062745388 hasLocation W20627453881 @default.