FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062748162> ?p ?o ?g. }

• W2062748162 endingPage "1114" @default.
• W2062748162 startingPage "1105" @default.
• W2062748162 abstract "Converging evidence suggests that the activation of the inflammatory cytokine pathway is important in the pathophysiology of unipolar depression. Antidepressants have anti-inflammatory properties and evidence suggests that inter-individual variability in response to antidepressants may reflect genetic differences in the inflammatory cytokine pathway. In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram. This study investigated the transcription of TNF, IL11 and IL6 as well as genes in the wider inflammatory cytokine pathway both at baseline and after escitalopram treatment in depressed patients who were either clinical responders (n=25) or non-responders (n=21). Samples were obtained as a subset of the Genome-Based Therapeutic Drugs for Depression (GENDEP) project and response status is based on changes in the Montgomery-Asberg Depression Rating Scores over a 12 wk treatment period. Binary logistic regressions revealed significant expression differences at baseline between responders and non-responders in TNF, and after escitalopram treatment in TNF and IL11. Differences in IL11 after treatment were found to be driven by drug-induced allele-specific expression differences relating to rs1126757. Top hits in the wider inflammatory cytokine pathway at both baseline and after escitalopram treatment were found to be targets of TNF. The current study adds substantial support for the role of the inflammatory cytokine pathway in mediating response to the SSRI escitalopram, and is the first to identify TNF and its targets as putative transcriptomic predictors of clinical response." @default.
• W2062748162 created "2016-06-24" @default.
• W2062748162 creator A5003157292 @default.
• W2062748162 creator A5006711140 @default.
• W2062748162 creator A5007752410 @default.
• W2062748162 creator A5018492307 @default.
• W2062748162 creator A5020397716 @default.
• W2062748162 creator A5036308969 @default.
• W2062748162 creator A5039359330 @default.
• W2062748162 creator A5045289228 @default.
• W2062748162 creator A5045978641 @default.
• W2062748162 creator A5052322797 @default.
• W2062748162 creator A5057837314 @default.
• W2062748162 creator A5064624409 @default.
• W2062748162 creator A5068135840 @default.
• W2062748162 creator A5081369396 @default.
• W2062748162 creator A5084729995 @default.
• W2062748162 date "2013-09-01" @default.
• W2062748162 modified "2023-09-27" @default.
• W2062748162 title "Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response" @default.
• W2062748162 cites W1489716577 @default.
• W2062748162 cites W1577577364 @default.
• W2062748162 cites W1963543965 @default.
• W2062748162 cites W1985438873 @default.
• W2062748162 cites W1987785379 @default.
• W2062748162 cites W1993586219 @default.
• W2062748162 cites W1996386643 @default.
• W2062748162 cites W1996454121 @default.
• W2062748162 cites W2004459473 @default.
• W2062748162 cites W2014970377 @default.
• W2062748162 cites W2044508901 @default.
• W2062748162 cites W2048431959 @default.
• W2062748162 cites W2052445727 @default.
• W2062748162 cites W2063237368 @default.
• W2062748162 cites W2065313926 @default.
• W2062748162 cites W2066027939 @default.
• W2062748162 cites W2092669597 @default.
• W2062748162 cites W2093663264 @default.
• W2062748162 cites W2094799749 @default.
• W2062748162 cites W2101646907 @default.
• W2062748162 cites W2105423509 @default.
• W2062748162 cites W2107277218 @default.
• W2062748162 cites W2108819694 @default.
• W2062748162 cites W2117754703 @default.
• W2062748162 cites W2130069961 @default.
• W2062748162 cites W2131823335 @default.
• W2062748162 cites W2151400960 @default.
• W2062748162 cites W2161633633 @default.
• W2062748162 cites W2333307249 @default.
• W2062748162 doi "https://doi.org/10.1016/j.euroneuro.2012.09.009" @default.
• W2062748162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23142150" @default.
• W2062748162 hasPublicationYear "2013" @default.
• W2062748162 type Work @default.
• W2062748162 sameAs 2062748162 @default.
• W2062748162 citedByCount "66" @default.
• W2062748162 countsByYear W20627481622013 @default.
• W2062748162 countsByYear W20627481622014 @default.
• W2062748162 countsByYear W20627481622015 @default.
• W2062748162 countsByYear W20627481622016 @default.
• W2062748162 countsByYear W20627481622017 @default.
• W2062748162 countsByYear W20627481622018 @default.
• W2062748162 countsByYear W20627481622019 @default.
• W2062748162 countsByYear W20627481622020 @default.
• W2062748162 countsByYear W20627481622021 @default.
• W2062748162 countsByYear W20627481622022 @default.
• W2062748162 countsByYear W20627481622023 @default.
• W2062748162 crossrefType "journal-article" @default.
• W2062748162 hasAuthorship W2062748162A5003157292 @default.
• W2062748162 hasAuthorship W2062748162A5006711140 @default.
• W2062748162 hasAuthorship W2062748162A5007752410 @default.
• W2062748162 hasAuthorship W2062748162A5018492307 @default.
• W2062748162 hasAuthorship W2062748162A5020397716 @default.
• W2062748162 hasAuthorship W2062748162A5036308969 @default.
• W2062748162 hasAuthorship W2062748162A5039359330 @default.
• W2062748162 hasAuthorship W2062748162A5045289228 @default.
• W2062748162 hasAuthorship W2062748162A5045978641 @default.
• W2062748162 hasAuthorship W2062748162A5052322797 @default.
• W2062748162 hasAuthorship W2062748162A5057837314 @default.
• W2062748162 hasAuthorship W2062748162A5064624409 @default.
• W2062748162 hasAuthorship W2062748162A5068135840 @default.
• W2062748162 hasAuthorship W2062748162A5081369396 @default.
• W2062748162 hasAuthorship W2062748162A5084729995 @default.
• W2062748162 hasConcept C126322002 @default.
• W2062748162 hasConcept C143998085 @default.
• W2062748162 hasConcept C17991360 @default.
• W2062748162 hasConcept C203014093 @default.
• W2062748162 hasConcept C2778690821 @default.
• W2062748162 hasConcept C2779144063 @default.
• W2062748162 hasConcept C2779177272 @default.
• W2062748162 hasConcept C2779583969 @default.
• W2062748162 hasConcept C2780051608 @default.
• W2062748162 hasConcept C2780092697 @default.
• W2062748162 hasConcept C2781161787 @default.
• W2062748162 hasConcept C60644358 @default.
• W2062748162 hasConcept C71924100 @default.
• W2062748162 hasConcept C86803240 @default.
• W2062748162 hasConcept C98274493 @default.
• W2062748162 hasConceptScore W2062748162C126322002 @default.

• next