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- W2062757328 abstract "Weanling male Spanish goats (n = 38) were randomly allotted to six treatment groups. Eight goats were positive controls; six goats were negative controls; six were given 2 transthoracic injections into the lung 21 d apart with 54 mg of purified Ph1 capsular polysaccharide (CPS) in agar beads; six had ultraviolet-killed Ph1 (1.4 × 109 CPU/ml) mixed with agar beads (Ph1-O); six had ultraviolet-killed Ph1 (8 × 109 CFU/ml) impregnated inside agar beads (Ph1-I); and six goats were given 2 subcutaneous injections 21 d apart with ultraviolet-killed Ph1 (8 × 109 CFU/ml) impregnated into agar beads (Ph1-I-SC). Thirteen d after the second injection all goats were challenge exposed to live Ph1 (1.93 × 108 CFU/ml) by transthoracic injection into the right lung, and 4 d later all goats were euthanatized and necropsied. Mean volume of consolidated lung tissue was: for the negative control group, 150.83 cm3; CPS group, 113.98 cm3; positive control group, 0.06 cm3; Ph1-O group, 11.68 cm3; Ph1-I group, 11.24 cm3; and Ph1-I-SC group, 33.47 cm3. There was a significant difference (P < 0.04) in lesion size among treatment groups. Mean values for treatment groups, positive control, Ph1-O, and Ph1-I were clustered together and all were considered immune. The Ph1-I-SC group was considered partially immune, and the NC and CPS groups were considered non-immune. All of the negative control goats died on d 35, five of the capsular group died by d 36. The transthoracicly injected, ultraviolet-irradiated whole cell bacterin, whether outside or inside the beads, was considered an excellent bacterin which induced solid immunity to a severe challenge exposure." @default.
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- W2062757328 date "1995-01-01" @default.
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- W2062757328 title "Efficacy of a capsule preparation and ultraviolet-killed Pasteurella haemolytica A1 vaccine in goats" @default.
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- W2062757328 doi "https://doi.org/10.1016/0921-4488(94)00009-v" @default.
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