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• W2062770355 abstract "Abstract Background YKL ‐40 may be involved in angiogenesis in psoriasis and psoriatic arthritis (PsA). High‐resolution power Doppler ultrasound ( PDUS ) can detect angiogenesis of synovium in PsA. Aim To assess serum YKL ‐40 in psoriasis patients with or without PsA, and to correlate its levels with disease activity and high‐resolution PDUS findings. Methods In this case–control study, 48 patients with psoriasis (26 of them also had PsA) and 30 controls were assessed by high‐resolution PDUS , and assayed for serum levels of YKL ‐40 by ELISA . Patients were clinically assessed using Composite Psoriatic Disease Activity Index ( CPDAI ). Total joint score ( TJS ) was used to assess joint involvement in PsA. Results A statistically significant elevation was found in YKL ‐40 levels in psoriatics with or without PsA compared with controls ( P < 0.001), as well as in PsA (group II ) compared to patients without arthritis (group I) ( P = 0.002). CPDAI , synovial thickness score and colour Doppler ultrasound ( CDUS ) score were highly significantly higher in group II vs. group I ( P < 0.001). In all patients, CPDAI , synovial thickness and CDUS score were positively correlated to each other, and each of them was positively correlated to serum YKL ‐40 levels ( P < 0.05). In either group I or II , serum YKL ‐40 levels correlated positively with CPDAI ( P < 0.05). In group II , TJS , synovial thickness and CDUS score were positively correlated to each other ( P < 0.05). Conclusions Serum YKL ‐40 can be used as a new biological marker for angiogenesis and disease activity in psoriasis with or without PsA. High‐resolution PDUS is a non‐invasive tool for the evaluation of angiogenesis in PsA patients as well as for the detection of early synovial changes in psoriasis patients without arthritis." @default.
• W2062770355 created "2016-06-24" @default.
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• W2062770355 date "2014-08-04" @default.
• W2062770355 modified "2023-09-25" @default.
• W2062770355 title "Serum YKL-40 in psoriasis with and without arthritis; correlation with disease activity and high-resolution power Doppler ultrasonographic joint findings" @default.
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• W2062770355 doi "https://doi.org/10.1111/jdv.12653" @default.
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