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• W2062785655 abstract "Abstract The cerebral frontal cortex of patients who had schizophrenia shows elevated levels of RNA for calcium/calmodulin‐dependent protein kinase II beta (CaMKIIβ). In addition, recent research shows that animal models for schizophrenia, such as amphetamine‐sensitized rats, consistently show elevated levels of D2 receptors in their high‐affinity state (D2 High ), the major target for antipsychotic medication. The present study was done, therefore, to examine whether an alteration in the levels of CaMKIIβ could lead to altered levels of D2 High receptors. We found that the CaMKII inhibitor, KN‐93, markedly reduced D2 High states in rat striatum. In addition, we studied heterozygous CaMKIIα knock‐out mice that show features analogous to schizophrenia. The striata of these mice revealed a 2.8‐fold increase in D2 High receptors. In frontal cortex of the heterozygous CaMKIIα knock‐out mice, CaMKIIα mRNA levels were reduced by 50%, while CaMKIIβ mRNA levels were unaltered. In striatum, CaMKIIβ mRNA levels were increased by 29%, suggesting the presence of a new CaMKIIβ regulatory pathway not previously described. The elevated levels of CaMKIIβ mRNA in the striatum suggest that this enzyme may increase D2 High in animals and possibly in schizophrenia itself. Synapse 64:794–800, 2010. © 2010 Wiley‐Liss, Inc." @default.
• W2062785655 created "2016-06-24" @default.
• W2062785655 creator A5004545899 @default.
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• W2062785655 date "2010-08-03" @default.
• W2062785655 modified "2023-10-16" @default.
• W2062785655 title "Hyperactive mice show elevated D2^Highreceptors, a model for schizophrenia: Calcium/calmodulin-dependent kinase II alpha knockouts" @default.
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• W2062785655 doi "https://doi.org/10.1002/syn.20786" @default.
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