FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062800186> ?p ?o ?g. }

• W2062800186 endingPage "9370" @default.
• W2062800186 startingPage "9365" @default.
• W2062800186 abstract "Staphylococcus aureus is a medically important bacterial pathogen that is a common cause of superficial and deep-seated abscesses in humans. Most S. aureus isolates produce either a serotype 5 or 8 capsular polysaccharide (CP) that has been shown to enhance bacterial virulence. We investigated the role of S. aureus CPs in modulating abscess formation in an experimental animal model of intraabdominal infection. Structural studies of CP8 revealed that it has a zwitterionic charge motif conferred by the negatively charged carboxyl group of N-acetylmannosaminuronic acid and free amino groups available on partially N-acetylated fucosamine residues. We report that purified CP5 and CP8 facilitated intraabdominal abscess formation in animals when given i.p. with a sterile cecal contents adjuvant. Chemical modifications that neutralized the positively or negatively charged groups on CP8 abrogated its ability to provoke abscesses. Rats prophylactically treated with CP8 s.c. were protected against abscess formation induced by homologous or heterologous zwitterionic polysaccharides. Likewise, treatment with CP8 protected against challenge with viable S. aureus strains PS80 (a capsule type 8 strain) or COL (a methicillin-resistant capsule type 5 strain). Purified CP8 was a potent activator of rat and human CD4(+) T cells in vitro. When transferred to naive rats, these activated T cells modulated the development of intraabdominal abscess formation. These results provide a structure/function rationale for abscess formation by S. aureus and expand the sphere of encapsulated organisms that interact directly with T cells to regulate this host response to bacterial infection." @default.
• W2062800186 created "2016-06-24" @default.
• W2062800186 creator A5021849616 @default.
• W2062800186 creator A5024064130 @default.
• W2062800186 creator A5078964300 @default.
• W2062800186 date "2001-07-24" @default.
• W2062800186 modified "2023-10-16" @default.
• W2062800186 title "Structural rationale for the modulation of abscess formation by<i>Staphylococcus aureus</i>capsular polysaccharides" @default.
• W2062800186 cites W1480606326 @default.
• W2062800186 cites W1531675548 @default.
• W2062800186 cites W1823444145 @default.
• W2062800186 cites W1831451590 @default.
• W2062800186 cites W1920836539 @default.
• W2062800186 cites W1940326586 @default.
• W2062800186 cites W1973215953 @default.
• W2062800186 cites W1980778694 @default.
• W2062800186 cites W1986218237 @default.
• W2062800186 cites W1990792235 @default.
• W2062800186 cites W1997393032 @default.
• W2062800186 cites W1998995307 @default.
• W2062800186 cites W2020421790 @default.
• W2062800186 cites W2032625989 @default.
• W2062800186 cites W2058522525 @default.
• W2062800186 cites W2062625837 @default.
• W2062800186 cites W2083215278 @default.
• W2062800186 cites W2087298783 @default.
• W2062800186 cites W2089646349 @default.
• W2062800186 cites W2110064610 @default.
• W2062800186 cites W2111872566 @default.
• W2062800186 cites W2119524661 @default.
• W2062800186 cites W2122011983 @default.
• W2062800186 cites W2136818130 @default.
• W2062800186 cites W2142257083 @default.
• W2062800186 cites W2143481959 @default.
• W2062800186 cites W2146243787 @default.
• W2062800186 cites W2154592972 @default.
• W2062800186 cites W2326873932 @default.
• W2062800186 cites W2475830216 @default.
• W2062800186 cites W3142636 @default.
• W2062800186 doi "https://doi.org/10.1073/pnas.161175598" @default.
• W2062800186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55426" @default.
• W2062800186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11470905" @default.
• W2062800186 hasPublicationYear "2001" @default.
• W2062800186 type Work @default.
• W2062800186 sameAs 2062800186 @default.
• W2062800186 citedByCount "126" @default.
• W2062800186 countsByYear W20628001862012 @default.
• W2062800186 countsByYear W20628001862013 @default.
• W2062800186 countsByYear W20628001862014 @default.
• W2062800186 countsByYear W20628001862015 @default.
• W2062800186 countsByYear W20628001862016 @default.
• W2062800186 countsByYear W20628001862017 @default.
• W2062800186 countsByYear W20628001862018 @default.
• W2062800186 countsByYear W20628001862019 @default.
• W2062800186 countsByYear W20628001862020 @default.
• W2062800186 countsByYear W20628001862021 @default.
• W2062800186 countsByYear W20628001862022 @default.
• W2062800186 countsByYear W20628001862023 @default.
• W2062800186 crossrefType "journal-article" @default.
• W2062800186 hasAuthorship W2062800186A5021849616 @default.
• W2062800186 hasAuthorship W2062800186A5024064130 @default.
• W2062800186 hasAuthorship W2062800186A5078964300 @default.
• W2062800186 hasBestOaLocation W20628001861 @default.
• W2062800186 hasConcept C10389963 @default.
• W2062800186 hasConcept C104317684 @default.
• W2062800186 hasConcept C155292618 @default.
• W2062800186 hasConcept C202751555 @default.
• W2062800186 hasConcept C2776460866 @default.
• W2062800186 hasConcept C2777035434 @default.
• W2062800186 hasConcept C2779489039 @default.
• W2062800186 hasConcept C523546767 @default.
• W2062800186 hasConcept C54355233 @default.
• W2062800186 hasConcept C55493867 @default.
• W2062800186 hasConcept C60987743 @default.
• W2062800186 hasConcept C86803240 @default.
• W2062800186 hasConcept C89423630 @default.
• W2062800186 hasConceptScore W2062800186C10389963 @default.
• W2062800186 hasConceptScore W2062800186C104317684 @default.
• W2062800186 hasConceptScore W2062800186C155292618 @default.
• W2062800186 hasConceptScore W2062800186C202751555 @default.
• W2062800186 hasConceptScore W2062800186C2776460866 @default.
• W2062800186 hasConceptScore W2062800186C2777035434 @default.
• W2062800186 hasConceptScore W2062800186C2779489039 @default.
• W2062800186 hasConceptScore W2062800186C523546767 @default.
• W2062800186 hasConceptScore W2062800186C54355233 @default.
• W2062800186 hasConceptScore W2062800186C55493867 @default.
• W2062800186 hasConceptScore W2062800186C60987743 @default.
• W2062800186 hasConceptScore W2062800186C86803240 @default.
• W2062800186 hasConceptScore W2062800186C89423630 @default.
• W2062800186 hasIssue "16" @default.
• W2062800186 hasLocation W20628001861 @default.
• W2062800186 hasLocation W20628001862 @default.
• W2062800186 hasLocation W20628001863 @default.
• W2062800186 hasLocation W20628001864 @default.
• W2062800186 hasOpenAccess W2062800186 @default.
• W2062800186 hasPrimaryLocation W20628001861 @default.
• W2062800186 hasRelatedWork W2037903640 @default.
• W2062800186 hasRelatedWork W2043777554 @default.

• next