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- W2062802178 abstract "We describe a microarray format that can detect double-stranded DNA sequences with a high degree of sequence selectivity. Cyclooctyne-derivatized pyrrole-imidazole polyamides were immobilized on azide-modified glass substrates using microcontact printing and a strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. These polyamide-immobilized substrates selectively detected a seven-base-pair binding site incorporated within a double-stranded oligodeoxyribonucleotide sequence even in the presence of an excess of a sequence with a single-base-pair mismatch." @default.
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- W2062802178 date "2013-02-21" @default.
- W2062802178 modified "2023-10-18" @default.
- W2062802178 title "Sequence-Selective Detection of Double-Stranded DNA Sequences Using Pyrrole–Imidazole Polyamide Microarrays" @default.
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- W2062802178 doi "https://doi.org/10.1021/ja309677h" @default.
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