FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062813149> ?p ?o ?g. }

• W2062813149 endingPage "1245" @default.
• W2062813149 startingPage "1239" @default.
• W2062813149 abstract "The bioreactor volume delineating the selection of primary clarification technology is not always easily defined. Development of a commercial scale process for the manufacture of therapeutic proteins requires scale‐up from a few liters to thousands of liters. While the separation techniques used for protein purification are largely conserved across scales, the separation techniques for primary cell culture clarification vary with scale. Process models were developed to compare monoclonal antibody production costs using two cell culture clarification technologies. One process model was created for cell culture clarification by disc stack centrifugation with depth filtration. A second process model was created for clarification by multi‐stage depth filtration. Analyses were performed to examine the influence of bioreactor volume, product titer, depth filter capacity, and facility utilization on overall operating costs. At bioreactor volumes <1,000 L, clarification using multi‐stage depth filtration offers cost savings compared to clarification using centrifugation. For bioreactor volumes >5,000 L, clarification using centrifugation followed by depth filtration offers significant cost savings. For bioreactor volumes of ∼2,000 L, clarification costs are similar between depth filtration and centrifugation. At this scale, factors including facility utilization, available capital, ease of process development, implementation timelines, and process performance characterization play an important role in clarification technology selection. In the case study presented, a multi‐product facility selected multi‐stage depth filtration for cell culture clarification at the 500 and 2,000 L scales of operation. Facility implementation timelines, process development activities, equipment commissioning and validation, scale‐up effects, and process robustness are examined. © 2013 The Authors. American Institute of Chemical Engineers Biotechnol. Prog ., 29:1239–1245, 2013" @default.
• W2062813149 created "2016-06-24" @default.
• W2062813149 creator A5048001655 @default.
• W2062813149 creator A5049329527 @default.
• W2062813149 creator A5055859254 @default.
• W2062813149 date "2013-07-11" @default.
• W2062813149 modified "2023-10-16" @default.
• W2062813149 title "Process cost and facility considerations in the selection of primary cell culture clarification technology" @default.
• W2062813149 cites W1585784812 @default.
• W2062813149 cites W1974302168 @default.
• W2062813149 cites W2004929411 @default.
• W2062813149 cites W2018033335 @default.
• W2062813149 cites W2023876635 @default.
• W2062813149 cites W2025559460 @default.
• W2062813149 cites W2037551042 @default.
• W2062813149 cites W2056621656 @default.
• W2062813149 cites W2069714986 @default.
• W2062813149 cites W2079581195 @default.
• W2062813149 cites W2082568784 @default.
• W2062813149 cites W2102502421 @default.
• W2062813149 cites W2128614206 @default.
• W2062813149 cites W2134238361 @default.
• W2062813149 cites W2159334408 @default.
• W2062813149 doi "https://doi.org/10.1002/btpr.1776" @default.
• W2062813149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23847160" @default.
• W2062813149 hasPublicationYear "2013" @default.
• W2062813149 type Work @default.
• W2062813149 sameAs 2062813149 @default.
• W2062813149 citedByCount "18" @default.
• W2062813149 countsByYear W20628131492014 @default.
• W2062813149 countsByYear W20628131492015 @default.
• W2062813149 countsByYear W20628131492016 @default.
• W2062813149 countsByYear W20628131492017 @default.
• W2062813149 countsByYear W20628131492018 @default.
• W2062813149 countsByYear W20628131492019 @default.
• W2062813149 countsByYear W20628131492020 @default.
• W2062813149 countsByYear W20628131492021 @default.
• W2062813149 countsByYear W20628131492022 @default.
• W2062813149 countsByYear W20628131492023 @default.
• W2062813149 crossrefType "journal-article" @default.
• W2062813149 hasAuthorship W2062813149A5048001655 @default.
• W2062813149 hasAuthorship W2062813149A5049329527 @default.
• W2062813149 hasAuthorship W2062813149A5055859254 @default.
• W2062813149 hasBestOaLocation W20628131491 @default.
• W2062813149 hasConcept C105795698 @default.
• W2062813149 hasConcept C111919701 @default.
• W2062813149 hasConcept C121332964 @default.
• W2062813149 hasConcept C127413603 @default.
• W2062813149 hasConcept C128489963 @default.
• W2062813149 hasConcept C150903083 @default.
• W2062813149 hasConcept C168170006 @default.
• W2062813149 hasConcept C178790620 @default.
• W2062813149 hasConcept C183696295 @default.
• W2062813149 hasConcept C185592680 @default.
• W2062813149 hasConcept C21880701 @default.
• W2062813149 hasConcept C2777874358 @default.
• W2062813149 hasConcept C2988729646 @default.
• W2062813149 hasConcept C33923547 @default.
• W2062813149 hasConcept C41008148 @default.
• W2062813149 hasConcept C41625074 @default.
• W2062813149 hasConcept C43617362 @default.
• W2062813149 hasConcept C53163501 @default.
• W2062813149 hasConcept C55493867 @default.
• W2062813149 hasConcept C74650414 @default.
• W2062813149 hasConcept C7623868 @default.
• W2062813149 hasConcept C86803240 @default.
• W2062813149 hasConcept C98045186 @default.
• W2062813149 hasConceptScore W2062813149C105795698 @default.
• W2062813149 hasConceptScore W2062813149C111919701 @default.
• W2062813149 hasConceptScore W2062813149C121332964 @default.
• W2062813149 hasConceptScore W2062813149C127413603 @default.
• W2062813149 hasConceptScore W2062813149C128489963 @default.
• W2062813149 hasConceptScore W2062813149C150903083 @default.
• W2062813149 hasConceptScore W2062813149C168170006 @default.
• W2062813149 hasConceptScore W2062813149C178790620 @default.
• W2062813149 hasConceptScore W2062813149C183696295 @default.
• W2062813149 hasConceptScore W2062813149C185592680 @default.
• W2062813149 hasConceptScore W2062813149C21880701 @default.
• W2062813149 hasConceptScore W2062813149C2777874358 @default.
• W2062813149 hasConceptScore W2062813149C2988729646 @default.
• W2062813149 hasConceptScore W2062813149C33923547 @default.
• W2062813149 hasConceptScore W2062813149C41008148 @default.
• W2062813149 hasConceptScore W2062813149C41625074 @default.
• W2062813149 hasConceptScore W2062813149C43617362 @default.
• W2062813149 hasConceptScore W2062813149C53163501 @default.
• W2062813149 hasConceptScore W2062813149C55493867 @default.
• W2062813149 hasConceptScore W2062813149C74650414 @default.
• W2062813149 hasConceptScore W2062813149C7623868 @default.
• W2062813149 hasConceptScore W2062813149C86803240 @default.
• W2062813149 hasConceptScore W2062813149C98045186 @default.
• W2062813149 hasIssue "5" @default.
• W2062813149 hasLocation W20628131491 @default.
• W2062813149 hasLocation W20628131492 @default.
• W2062813149 hasOpenAccess W2062813149 @default.
• W2062813149 hasPrimaryLocation W20628131491 @default.
• W2062813149 hasRelatedWork W162673787 @default.
• W2062813149 hasRelatedWork W1636917044 @default.
• W2062813149 hasRelatedWork W1653943910 @default.

• next