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- W2062816809 abstract "Cytomegalovirus (CMV) remains a major cause of morbidity and mortality among transplant recipients, frequently engaging the clinician in a struggle to balance graft preservation with control of CMV disease. Leflunomide has been shown to have immunosuppressive activity in experimental allograft models together with antiviral activity inhibiting CMV both in vitro and in vivo. Data are emerging about its potential role in ganciclovir-sensitive and -resistant CMV, primarily by virtue of a unique mechanism inhibiting virion assembly, as opposed to inhibition of viral DNA synthesis by current agents. This review aims to put in perspective, the knowledge acquired in the last decade or so on leflunomide for CMV. Evidence suggests that it might have activity against human CMV with good oral bioavailability and, more importantly in the resource-poor setting, is economical. Although the data presented here are not from randomized trials, several relevant observations have been made that could influence future, more structured assessments of the drug. An immune suppressive compound with antiviral features and experimental activity in chronic rejection is an attractive combination for organ transplantation, and it appears that leflunomide may just fit that niche." @default.
- W2062816809 created "2016-06-24" @default.
- W2062816809 creator A5054156717 @default.
- W2062816809 creator A5086952950 @default.
- W2062816809 date "2011-10-09" @default.
- W2062816809 modified "2023-10-09" @default.
- W2062816809 title "Leflunomide for cytomegalovirus: bench to bedside" @default.
- W2062816809 cites W1965169112 @default.
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- W2062816809 cites W1973273390 @default.
- W2062816809 cites W1975696256 @default.
- W2062816809 cites W1981217826 @default.
- W2062816809 cites W1981692602 @default.
- W2062816809 cites W1986490574 @default.
- W2062816809 cites W1988264048 @default.
- W2062816809 cites W1989700483 @default.
- W2062816809 cites W1992412514 @default.
- W2062816809 cites W1997638411 @default.
- W2062816809 cites W1998237249 @default.
- W2062816809 cites W2008397578 @default.
- W2062816809 cites W2008692318 @default.
- W2062816809 cites W2011316657 @default.
- W2062816809 cites W2013222094 @default.
- W2062816809 cites W2017469324 @default.
- W2062816809 cites W2022251566 @default.
- W2062816809 cites W2032247890 @default.
- W2062816809 cites W2036048816 @default.
- W2062816809 cites W2043260338 @default.
- W2062816809 cites W2047214508 @default.
- W2062816809 cites W2049007610 @default.
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- W2062816809 doi "https://doi.org/10.1111/j.1399-3062.2011.00682.x" @default.
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