FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062821836> ?p ?o ?g. }

• W2062821836 endingPage "e2545" @default.
• W2062821836 startingPage "e2545" @default.
• W2062821836 abstract "Extreme climatic conditions may alter historic host-pathogen relationships and synchronize the temporal and spatial convergence of multiple infectious agents, triggering epidemics with far greater mortality than those due to single pathogens. Here we present the first data to clearly illustrate how climate extremes can promote a complex interplay between epidemic and endemic pathogens that are normally tolerated in isolation, but with co-infection, result in catastrophic mortality. A 1994 canine distemper virus (CDV) epidemic in Serengeti lions (Panthera leo) coincided with the death of a third of the population, and a second high-mortality CDV epidemic struck the nearby Ngorongoro Crater lion population in 2001. The extent of adult mortalities was unusual for CDV and prompted an investigation into contributing factors. Serological analyses indicated that at least five “silent” CDV epidemics swept through the same two lion populations between 1976 and 2006 without clinical signs or measurable mortality, indicating that CDV was not necessarily fatal. Clinical and pathology findings suggested that hemoparsitism was a major contributing factor during fatal epidemics. Using quantitative real-time PCR, we measured the magnitude of hemoparasite infections in these populations over 22 years and demonstrated significantly higher levels of Babesia during the 1994 and 2001 epidemics. Babesia levels correlated with mortalities and extent of CDV exposure within prides. The common event preceding the two high mortality CDV outbreaks was extreme drought conditions with wide-spread herbivore die-offs, most notably of Cape buffalo (Syncerus caffer). As a consequence of high tick numbers after the resumption of rains and heavy tick infestations of starving buffalo, the lions were infected by unusually high numbers of Babesia, infections that were magnified by the immunosuppressive effects of coincident CDV, leading to unprecedented mortality. Such mass mortality events may become increasingly common if climate extremes disrupt historic stable relationships between co-existing pathogens and their susceptible hosts." @default.
• W2062821836 created "2016-06-24" @default.
• W2062821836 creator A5009819587 @default.
• W2062821836 creator A5032408966 @default.
• W2062821836 creator A5038843891 @default.
• W2062821836 creator A5042895504 @default.
• W2062821836 creator A5053639405 @default.
• W2062821836 creator A5062699674 @default.
• W2062821836 creator A5073536278 @default.
• W2062821836 creator A5078362825 @default.
• W2062821836 creator A5084869322 @default.
• W2062821836 date "2008-06-25" @default.
• W2062821836 modified "2023-10-09" @default.
• W2062821836 title "Climate Extremes Promote Fatal Co-Infections during Canine Distemper Epidemics in African Lions" @default.
• W2062821836 cites W1547319888 @default.
• W2062821836 cites W1760054562 @default.
• W2062821836 cites W1972148604 @default.
• W2062821836 cites W1987756752 @default.
• W2062821836 cites W2081682304 @default.
• W2062821836 cites W2086060397 @default.
• W2062821836 cites W2086899901 @default.
• W2062821836 cites W2087530582 @default.
• W2062821836 cites W2092362413 @default.
• W2062821836 cites W2099121311 @default.
• W2062821836 cites W2106190670 @default.
• W2062821836 cites W2106686920 @default.
• W2062821836 cites W2115597221 @default.
• W2062821836 cites W2123882751 @default.
• W2062821836 cites W2128232632 @default.
• W2062821836 cites W2132958863 @default.
• W2062821836 cites W2143119245 @default.
• W2062821836 cites W2151399155 @default.
• W2062821836 cites W2178828427 @default.
• W2062821836 doi "https://doi.org/10.1371/journal.pone.0002545" @default.
• W2062821836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2435602" @default.
• W2062821836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18575601" @default.
• W2062821836 hasPublicationYear "2008" @default.
• W2062821836 type Work @default.
• W2062821836 sameAs 2062821836 @default.
• W2062821836 citedByCount "182" @default.
• W2062821836 countsByYear W20628218362012 @default.
• W2062821836 countsByYear W20628218362013 @default.
• W2062821836 countsByYear W20628218362014 @default.
• W2062821836 countsByYear W20628218362015 @default.
• W2062821836 countsByYear W20628218362016 @default.
• W2062821836 countsByYear W20628218362017 @default.
• W2062821836 countsByYear W20628218362018 @default.
• W2062821836 countsByYear W20628218362019 @default.
• W2062821836 countsByYear W20628218362020 @default.
• W2062821836 countsByYear W20628218362021 @default.
• W2062821836 countsByYear W20628218362022 @default.
• W2062821836 countsByYear W20628218362023 @default.
• W2062821836 crossrefType "journal-article" @default.
• W2062821836 hasAuthorship W2062821836A5009819587 @default.
• W2062821836 hasAuthorship W2062821836A5032408966 @default.
• W2062821836 hasAuthorship W2062821836A5038843891 @default.
• W2062821836 hasAuthorship W2062821836A5042895504 @default.
• W2062821836 hasAuthorship W2062821836A5053639405 @default.
• W2062821836 hasAuthorship W2062821836A5062699674 @default.
• W2062821836 hasAuthorship W2062821836A5073536278 @default.
• W2062821836 hasAuthorship W2062821836A5078362825 @default.
• W2062821836 hasAuthorship W2062821836A5084869322 @default.
• W2062821836 hasBestOaLocation W20628218361 @default.
• W2062821836 hasConcept C116675565 @default.
• W2062821836 hasConcept C142724271 @default.
• W2062821836 hasConcept C159047783 @default.
• W2062821836 hasConcept C2522874641 @default.
• W2062821836 hasConcept C2776040883 @default.
• W2062821836 hasConcept C2779134260 @default.
• W2062821836 hasConcept C2780581805 @default.
• W2062821836 hasConcept C2908647359 @default.
• W2062821836 hasConcept C3008058167 @default.
• W2062821836 hasConcept C524204448 @default.
• W2062821836 hasConcept C71924100 @default.
• W2062821836 hasConcept C86803240 @default.
• W2062821836 hasConcept C89623803 @default.
• W2062821836 hasConcept C99454951 @default.
• W2062821836 hasConceptScore W2062821836C116675565 @default.
• W2062821836 hasConceptScore W2062821836C142724271 @default.
• W2062821836 hasConceptScore W2062821836C159047783 @default.
• W2062821836 hasConceptScore W2062821836C2522874641 @default.
• W2062821836 hasConceptScore W2062821836C2776040883 @default.
• W2062821836 hasConceptScore W2062821836C2779134260 @default.
• W2062821836 hasConceptScore W2062821836C2780581805 @default.
• W2062821836 hasConceptScore W2062821836C2908647359 @default.
• W2062821836 hasConceptScore W2062821836C3008058167 @default.
• W2062821836 hasConceptScore W2062821836C524204448 @default.
• W2062821836 hasConceptScore W2062821836C71924100 @default.
• W2062821836 hasConceptScore W2062821836C86803240 @default.
• W2062821836 hasConceptScore W2062821836C89623803 @default.
• W2062821836 hasConceptScore W2062821836C99454951 @default.
• W2062821836 hasIssue "6" @default.
• W2062821836 hasLocation W20628218361 @default.
• W2062821836 hasLocation W20628218362 @default.
• W2062821836 hasLocation W20628218363 @default.
• W2062821836 hasLocation W20628218364 @default.
• W2062821836 hasLocation W20628218365 @default.
• W2062821836 hasLocation W20628218366 @default.

• next