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• W2062821855 abstract "Celiac disease (CD) or gluten-sensitive enteropathy is an inflammatory disorder of the small intestine, caused by exposure to dietary gluten in genetically susceptible individuals. Dietary gluten provokes inflammation in the small intestine characterized by accumulation of the intraepithelial lymphocytes, development of crypt hyperplasia, and, ultimately, villous atrophy. In the majority of cases, the disease enters complete clinical and histologic remission when gluten is eliminated from the diet. Until fairly recently, CD was thought to be a relatively rare disorder with prevalence rates < 0.1% [1]. More recent studies showed that celiac sprue is a common disease affecting on average one in 200 white individuals [2,3]. This change in prevalence may be related to increasing physicians’ awareness of the silent nature of CD as well to improved diagnostic methods. The diagnosis of CD may be difficult because only a proportion of those with histologic abnormalities exhibit classical symptoms of CD. More than 50% of CD patients have no gastrointestinal (GI) symptoms or only nonspecific complaints, such as dyspepsia or anorexia [4–6]. The analogy of an iceberg was suggested for CD, meaning that only a small portion of patients with classic symptoms are diagnosed, whereas the majority of asymptomatic individuals or subjects with mild, nonspecific symptoms remains undiagnosed and untreated" @default.
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• W2062821855 date "2004-01-01" @default.
• W2062821855 modified "2023-09-23" @default.
• W2062821855 title "Given capsule endoscopy in celiac disease" @default.
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• W2062821855 doi "https://doi.org/10.1016/j.giec.2003.10.005" @default.
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