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- W2062832170 abstract "T cells express receptors for antigen on their surface (TcR) which consist either of α/β or of γ/δ polypeptide chains. Since the TcR δ chain gene is located within the TcR α chain gene locus, strict regulation of expression of the region must operate to ensure that the two loci are not concomitantly expressed in T cells bearing either α/β or γ/δ TcR. In this report it is demonstrated that elements within the mouse TcR δ gene locus, located between the Jδ2 and Cδ exons, enhance transcription from a heterologous promoter five- to tenfold in a T cell hybridoma expressing a TcR γ/δ, whereas enhancement was only twofold in an α/β-bearing T cell hybridoma. No enhancement of expression was observed in a B cell hybridoma. The sequences responsible for this enhancing activity are largely confined to a 766-bp Hae III DNA restriction fragment. A region within this DNA segment shows significant homology (73% identify) to a recently identified enhancer of the human TcR δ gene locus." @default.
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- W2062832170 date "1991-03-01" @default.
- W2062832170 modified "2023-10-14" @default.
- W2062832170 title "A transcriptional enhancer of the mouse T cell receptor δ gene locus" @default.
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- W2062832170 doi "https://doi.org/10.1002/eji.1830210339" @default.
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