Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062844908> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2062844908 abstract "Guinea pig lung tissue is dramatically depleted of S-adenosyl-L-homocysteine (SAH) after chronic exposure (600 micrograms/h s.c. for 21 days) of animals to either R-(+)- or S-(-)-nicotine enantiomers; S-(-)-nicotine decreased lung SAH levels by 60-fold, while R-(+)-nicotine caused an 11-fold reduction of SAH, relative to control values. Lung S-adenosyl-L-methionine (SAM) levels were also reduced (15-fold and 9-fold reductions with R-(+)- and S-(-)-isomers, respectively) in nicotine-treated animals, compared to controls. These depletions are more pronounced with the S-(-)-enantiomer. Liver tissue levels of SAH and SAM are less affected, in fact, a 4-fold increase in liver SAH levels was observed after exposure of animals to R-(+)-nicotine. These results indicate that chronic exposure to nicotine may perturb important endogenous methyltransferase reactions, which could be a contributory factor in the toxicological effects produced by cigarette smoking." @default.
- W2062844908 created "2016-06-24" @default.
- W2062844908 creator A5045085436 @default.
- W2062844908 creator A5083049265 @default.
- W2062844908 date "1986-04-01" @default.
- W2062844908 modified "2023-09-26" @default.
- W2062844908 title "In vivo depletion of S-adenosyl-l-homocysteine and S-adenosyl-l-methionine in guinea pig lung after chronic S-(−)-nicotine administration" @default.
- W2062844908 cites W1531774225 @default.
- W2062844908 cites W1970653660 @default.
- W2062844908 cites W1993550860 @default.
- W2062844908 cites W2038557175 @default.
- W2062844908 cites W2052903512 @default.
- W2062844908 cites W2059713327 @default.
- W2062844908 cites W2070683041 @default.
- W2062844908 cites W2077949190 @default.
- W2062844908 cites W2080210174 @default.
- W2062844908 cites W2093323025 @default.
- W2062844908 cites W2094172864 @default.
- W2062844908 cites W2142874652 @default.
- W2062844908 cites W2408583011 @default.
- W2062844908 cites W2416870162 @default.
- W2062844908 doi "https://doi.org/10.1016/0378-4274(86)90190-6" @default.
- W2062844908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3715913" @default.
- W2062844908 hasPublicationYear "1986" @default.
- W2062844908 type Work @default.
- W2062844908 sameAs 2062844908 @default.
- W2062844908 citedByCount "10" @default.
- W2062844908 countsByYear W20628449082013 @default.
- W2062844908 countsByYear W20628449082022 @default.
- W2062844908 crossrefType "journal-article" @default.
- W2062844908 hasAuthorship W2062844908A5045085436 @default.
- W2062844908 hasAuthorship W2062844908A5083049265 @default.
- W2062844908 hasConcept C104317684 @default.
- W2062844908 hasConcept C126322002 @default.
- W2062844908 hasConcept C134018914 @default.
- W2062844908 hasConcept C150903083 @default.
- W2062844908 hasConcept C185592680 @default.
- W2062844908 hasConcept C207001950 @default.
- W2062844908 hasConcept C2777090595 @default.
- W2062844908 hasConcept C2777714996 @default.
- W2062844908 hasConcept C2778815084 @default.
- W2062844908 hasConcept C2779547902 @default.
- W2062844908 hasConcept C2780912031 @default.
- W2062844908 hasConcept C33288867 @default.
- W2062844908 hasConcept C515207424 @default.
- W2062844908 hasConcept C55493867 @default.
- W2062844908 hasConcept C71924100 @default.
- W2062844908 hasConcept C86803240 @default.
- W2062844908 hasConcept C91965660 @default.
- W2062844908 hasConcept C98274493 @default.
- W2062844908 hasConceptScore W2062844908C104317684 @default.
- W2062844908 hasConceptScore W2062844908C126322002 @default.
- W2062844908 hasConceptScore W2062844908C134018914 @default.
- W2062844908 hasConceptScore W2062844908C150903083 @default.
- W2062844908 hasConceptScore W2062844908C185592680 @default.
- W2062844908 hasConceptScore W2062844908C207001950 @default.
- W2062844908 hasConceptScore W2062844908C2777090595 @default.
- W2062844908 hasConceptScore W2062844908C2777714996 @default.
- W2062844908 hasConceptScore W2062844908C2778815084 @default.
- W2062844908 hasConceptScore W2062844908C2779547902 @default.
- W2062844908 hasConceptScore W2062844908C2780912031 @default.
- W2062844908 hasConceptScore W2062844908C33288867 @default.
- W2062844908 hasConceptScore W2062844908C515207424 @default.
- W2062844908 hasConceptScore W2062844908C55493867 @default.
- W2062844908 hasConceptScore W2062844908C71924100 @default.
- W2062844908 hasConceptScore W2062844908C86803240 @default.
- W2062844908 hasConceptScore W2062844908C91965660 @default.
- W2062844908 hasConceptScore W2062844908C98274493 @default.
- W2062844908 hasLocation W20628449081 @default.
- W2062844908 hasLocation W20628449082 @default.
- W2062844908 hasOpenAccess W2062844908 @default.
- W2062844908 hasPrimaryLocation W20628449081 @default.
- W2062844908 hasRelatedWork W1987503858 @default.
- W2062844908 hasRelatedWork W2042242548 @default.
- W2062844908 hasRelatedWork W2043134151 @default.
- W2062844908 hasRelatedWork W2077657414 @default.
- W2062844908 hasRelatedWork W2084989677 @default.
- W2062844908 hasRelatedWork W2327675433 @default.
- W2062844908 hasRelatedWork W2329765870 @default.
- W2062844908 hasRelatedWork W2412824661 @default.
- W2062844908 hasRelatedWork W2768833441 @default.
- W2062844908 hasRelatedWork W2899084033 @default.
- W2062844908 isParatext "false" @default.
- W2062844908 isRetracted "false" @default.
- W2062844908 magId "2062844908" @default.
- W2062844908 workType "article" @default.