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• W2062847782 abstract "The maximal response of thyrotropin (TSH) to thyrotropin-releasing hormone (TRH) (Δ max TSH) is reduced in endogenous depression (ED). In the majority of studies Δ max TSH was reduced to the same degree in unipolar and bipolar depression, as well as in manic patients. Decreases present in anorexia nervosa and heroin addiction possibly were secondary to reduced caloric intake and administration of heroin, respectively. When the TRH test was repeated in patients with ED who were clinically cured after short-term antidepressant therapy, the patients could be divided into two groups, one with an increase of Δ max TSH > 2.0 μU/ml, and another with an increase <-2.0 μU/ml. After withdrawal of treatment, patients in the former group did well for at least six months, whereas patients in the latter group relapsed within a median time of two months. Predictions were correct in 60 of 66 patients. However, the change of the TSH response during the course of ED is relatively small, and thus great care should be taken to diminish both the analytical and the normal biological variations. Electroconvulsive therapy (ECT), tricyclic antidepressants, tryptophan and sleep deprivation, respectively, did not influence Δ max TSH, whereas lithium, because of an inhibition of thyroid hormone release and negative feedback, induced an increase of Δ max TSH unrelated to the course of ED. p] Although serum levels of the thyroid hormones and cortisol changed during the course of ED, no relationship could be demonstrated between Δ max TSH on the one hand and the free serum levels of thyroxine and 3,3′,5-triiodothyronine, as expressed by the free indices, or the serum levels of cortisol, on the other hand. Neither did Δ max TSH in the depressed patients correlate significantly with the cerebrospinal fluid (CSF) levels of thyroxine, cortisol or TRH. Thus, CSF levels of TRH were unrelated to the clinical outcome of ED, but 70% of the values exceeded the upper range of neurologic controls. Therefore, it is possible that CSF TRH might be of diagnostic value in patients with ED." @default.
• W2062847782 created "2016-06-24" @default.
• W2062847782 creator A5005252606 @default.
• W2062847782 date "1981-01-01" @default.
• W2062847782 modified "2023-10-06" @default.
• W2062847782 title "The thyrotropin response to thyrotropin-releasing hormone in endogenous depression" @default.
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