FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062854498> ?p ?o ?g. }

• W2062854498 abstract "BackgroundWe are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.MethodsTwenty-three SDs and twenty SHRs were randomized into four groups subjected to 90 minutes tMCAo or sham. BrdU (50 mg/kg) was administered intraperitoneally twice daily on Day 4 to 7 after surgery. On Day 8 all animals were euthanized. NeuN-stained tissue sections were used for brain and infarct volume estimation with the 2D nucleator and Cavalieri principle. Brains were studied for the presence of activated microglia (ED-1) and hippocampal BrdU incorporation using the optical fractionator.ResultsWe found no significant difference or increase in post-ischemic NPC proliferation between the two strains. However, the response to remote ischemia may differ between SDs and SHRs. In three animals increased post-stroke NPC proliferation was associated with hippocampal ischemic injury. The mean infarct volume was 89.2 ± 76.1 mm3 in SHRs and 16.9 ± 22.7 mm3 in SDs (p < 0.005). Eight out of eleven SHRs had ischemic neocortical damage in contrast to only one out of 12 SDs. We observed involvement of the anterior choroidal and hypothalamic arteries in several animals from both strains and the anterior cerebral artery in two SHRs.ConclusionsWe found no evidence of an early hippocampal NPC proliferation one week after tMCAo in both strains. Infarction within the anterior choroidal artery could induce hippocampal ischemia and increase NPC proliferation profoundly. NPC proliferation was not aggravated by the presence of activated microglia. Intraluminal tMCAo in SHRs gave a more reliable infarct with neocortical involvement, but affected territories supplied by the anterior cerebral, anterior choroidal and hypothalamic arteries." @default.
• W2062854498 created "2016-06-24" @default.
• W2062854498 creator A5014226679 @default.
• W2062854498 creator A5033056096 @default.
• W2062854498 creator A5033337407 @default.
• W2062854498 creator A5037650368 @default.
• W2062854498 creator A5062934979 @default.
• W2062854498 creator A5066252280 @default.
• W2062854498 creator A5069780663 @default.
• W2062854498 creator A5087318688 @default.
• W2062854498 creator A5089518876 @default.
• W2062854498 date "2010-04-06" @default.
• W2062854498 modified "2023-10-15" @default.
• W2062854498 title "Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools" @default.
• W2062854498 cites W1563590122 @default.
• W2062854498 cites W1889743606 @default.
• W2062854498 cites W1906569886 @default.
• W2062854498 cites W1929544011 @default.
• W2062854498 cites W1965527402 @default.
• W2062854498 cites W1971391716 @default.
• W2062854498 cites W1971668430 @default.
• W2062854498 cites W1972498556 @default.
• W2062854498 cites W1972737397 @default.
• W2062854498 cites W1976678881 @default.
• W2062854498 cites W1976882355 @default.
• W2062854498 cites W1978525572 @default.
• W2062854498 cites W1984971671 @default.
• W2062854498 cites W1989014567 @default.
• W2062854498 cites W1994536765 @default.
• W2062854498 cites W2004240294 @default.
• W2062854498 cites W2010395737 @default.
• W2062854498 cites W2010633131 @default.
• W2062854498 cites W2020362442 @default.
• W2062854498 cites W2020500819 @default.
• W2062854498 cites W2022593257 @default.
• W2062854498 cites W2023884158 @default.
• W2062854498 cites W2025427496 @default.
• W2062854498 cites W2037367554 @default.
• W2062854498 cites W2038054506 @default.
• W2062854498 cites W2043822586 @default.
• W2062854498 cites W2044273670 @default.
• W2062854498 cites W2051021067 @default.
• W2062854498 cites W2059307876 @default.
• W2062854498 cites W2064906534 @default.
• W2062854498 cites W2065498565 @default.
• W2062854498 cites W2066176018 @default.
• W2062854498 cites W2068210940 @default.
• W2062854498 cites W2069445669 @default.
• W2062854498 cites W2071646614 @default.
• W2062854498 cites W2073221687 @default.
• W2062854498 cites W2073521129 @default.
• W2062854498 cites W2075737515 @default.
• W2062854498 cites W2077500496 @default.
• W2062854498 cites W2085160890 @default.
• W2062854498 cites W2087038357 @default.
• W2062854498 cites W2092612284 @default.
• W2062854498 cites W2105382539 @default.
• W2062854498 cites W2107915390 @default.
• W2062854498 cites W2108938764 @default.
• W2062854498 cites W2109759840 @default.
• W2062854498 cites W2111405228 @default.
• W2062854498 cites W2112505121 @default.
• W2062854498 cites W2117440560 @default.
• W2062854498 cites W2120003285 @default.
• W2062854498 cites W2130929362 @default.
• W2062854498 cites W2132823130 @default.
• W2062854498 cites W2137168148 @default.
• W2062854498 cites W2141787500 @default.
• W2062854498 cites W2155885439 @default.
• W2062854498 cites W2162661261 @default.
• W2062854498 cites W2167181354 @default.
• W2062854498 cites W2168272960 @default.
• W2062854498 cites W2171390081 @default.
• W2062854498 cites W2484004922 @default.
• W2062854498 cites W4253368331 @default.
• W2062854498 cites W4253449373 @default.
• W2062854498 cites W4255932613 @default.
• W2062854498 doi "https://doi.org/10.1186/2040-7378-2-8" @default.
• W2062854498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868803" @default.
• W2062854498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20370927" @default.
• W2062854498 hasPublicationYear "2010" @default.
• W2062854498 type Work @default.
• W2062854498 sameAs 2062854498 @default.
• W2062854498 citedByCount "5" @default.
• W2062854498 countsByYear W20628544982012 @default.
• W2062854498 countsByYear W20628544982013 @default.
• W2062854498 countsByYear W20628544982017 @default.
• W2062854498 crossrefType "journal-article" @default.
• W2062854498 hasAuthorship W2062854498A5014226679 @default.
• W2062854498 hasAuthorship W2062854498A5033056096 @default.
• W2062854498 hasAuthorship W2062854498A5033337407 @default.
• W2062854498 hasAuthorship W2062854498A5037650368 @default.
• W2062854498 hasAuthorship W2062854498A5062934979 @default.
• W2062854498 hasAuthorship W2062854498A5066252280 @default.
• W2062854498 hasAuthorship W2062854498A5069780663 @default.
• W2062854498 hasAuthorship W2062854498A5087318688 @default.
• W2062854498 hasAuthorship W2062854498A5089518876 @default.
• W2062854498 hasBestOaLocation W20628544981 @default.
• W2062854498 hasConcept C126322002 @default.
• W2062854498 hasConcept C127413603 @default.

• next