Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062855236> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2062855236 endingPage "340" @default.
- W2062855236 startingPage "336" @default.
- W2062855236 abstract "Guinea pigs were injected intradermally with 5 mg, 0.5 mg, and 0.05mg of the following compounds: zirconium carbonate (ZrCO 3 ), aluminum chlorhydrate (ACH), and zirconium aluminum glycine complex (ZAGS), or 6.5 mg, 0.65 mg, and 0.065mg of aluminum hydroxide (Al(OH) 3 ), in 0.1ml of saline. Al(OH) 3 produced measurable granulomas with the 6.5-mg and 0.65-mg doses; those produced by the 6.5-mg dose persisted for over 28 days. No increase in skin thickness was detected with ZrCO 3 . Histologic examination of the Al(OH) 3 granulomas revealed large undifferentiated macrophages and occasional giant cells surrounding the area containing the injected material. There was little evidence of infiltration with other inflammatory cells and no evidence of fibrosis, although there was always some degree of central necrosis. While ZrCO 3 induced no measurable granulomas, the injection site usually contained a small collection of macrophages that had ingested crystalline material. Both ACH and ZAGS produced increases in skin thickness even at the 0.05-mg dos. This began 14 days after injection, and reached a maximum at 21 days. Histologically, the lesions showed granulomas which consisted of shredded bundles of intensely basophilic collagen, which also stained with Weigert's elastic stain. This area contained many giant cells and histiocytes, which were markedly pleomorphic, strongly hyperchromatic, and occasionally phagocytic. This process was succeeded by intense fibrosis. The changes in collagen could be the same as those seen in senile elastosis." @default.
- W2062855236 created "2016-06-24" @default.
- W2062855236 creator A5052701988 @default.
- W2062855236 creator A5089346639 @default.
- W2062855236 date "1977-06-01" @default.
- W2062855236 modified "2023-09-27" @default.
- W2062855236 title "Granuloma Formation in Normal Guinea Pigs Injected Interadermally With Aluminum and Zirconium Compounds" @default.
- W2062855236 cites W1986308979 @default.
- W2062855236 cites W1988721835 @default.
- W2062855236 cites W2057060853 @default.
- W2062855236 cites W2112826901 @default.
- W2062855236 doi "https://doi.org/10.1111/1523-1747.ep12496358" @default.
- W2062855236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/864274" @default.
- W2062855236 hasPublicationYear "1977" @default.
- W2062855236 type Work @default.
- W2062855236 sameAs 2062855236 @default.
- W2062855236 citedByCount "62" @default.
- W2062855236 countsByYear W20628552362012 @default.
- W2062855236 countsByYear W20628552362014 @default.
- W2062855236 countsByYear W20628552362016 @default.
- W2062855236 countsByYear W20628552362019 @default.
- W2062855236 countsByYear W20628552362020 @default.
- W2062855236 countsByYear W20628552362021 @default.
- W2062855236 crossrefType "journal-article" @default.
- W2062855236 hasAuthorship W2062855236A5052701988 @default.
- W2062855236 hasAuthorship W2062855236A5089346639 @default.
- W2062855236 hasBestOaLocation W20628552361 @default.
- W2062855236 hasConcept C126322002 @default.
- W2062855236 hasConcept C142724271 @default.
- W2062855236 hasConcept C179104552 @default.
- W2062855236 hasConcept C185592680 @default.
- W2062855236 hasConcept C2778815084 @default.
- W2062855236 hasConcept C2780140890 @default.
- W2062855236 hasConcept C534791751 @default.
- W2062855236 hasConcept C71924100 @default.
- W2062855236 hasConceptScore W2062855236C126322002 @default.
- W2062855236 hasConceptScore W2062855236C142724271 @default.
- W2062855236 hasConceptScore W2062855236C179104552 @default.
- W2062855236 hasConceptScore W2062855236C185592680 @default.
- W2062855236 hasConceptScore W2062855236C2778815084 @default.
- W2062855236 hasConceptScore W2062855236C2780140890 @default.
- W2062855236 hasConceptScore W2062855236C534791751 @default.
- W2062855236 hasConceptScore W2062855236C71924100 @default.
- W2062855236 hasIssue "6" @default.
- W2062855236 hasLocation W20628552361 @default.
- W2062855236 hasLocation W20628552362 @default.
- W2062855236 hasOpenAccess W2062855236 @default.
- W2062855236 hasPrimaryLocation W20628552361 @default.
- W2062855236 hasRelatedWork W1980905919 @default.
- W2062855236 hasRelatedWork W2059630215 @default.
- W2062855236 hasRelatedWork W2063285133 @default.
- W2062855236 hasRelatedWork W2393505409 @default.
- W2062855236 hasRelatedWork W2401092517 @default.
- W2062855236 hasRelatedWork W2408422835 @default.
- W2062855236 hasRelatedWork W2748952813 @default.
- W2062855236 hasRelatedWork W2899084033 @default.
- W2062855236 hasRelatedWork W2941827502 @default.
- W2062855236 hasRelatedWork W2951727615 @default.
- W2062855236 hasVolume "68" @default.
- W2062855236 isParatext "false" @default.
- W2062855236 isRetracted "false" @default.
- W2062855236 magId "2062855236" @default.
- W2062855236 workType "article" @default.