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- W2062858146 abstract "ABSTRACT A genetic screen for cell division cycle mutants of Caulobacter crescentus identified a temperature-sensitive DNA replication mutant. Genetic complementation experiments revealed a mutation within the dnaE gene, encoding the α-catalytic subunit of DNA polymerase III holoenzyme. Sequencing of the temperature-sensitive dnaE allele indicated a single base pair substitution resulting in a change from valine to glutamic acid within the C-terminal portion of the protein. This mutation lies in a region of the DnaE protein shown in Escherichia coli , to be important in interactions with other essential DNA replication proteins. Using DNA replication assays and fluorescence flow cytometry, we show that the observed block in DNA synthesis in the Caulobacter dnaE mutant strain occurs at the initiation stage of replication and that there is also a partial block of DNA elongation." @default.
- W2062858146 created "2016-06-24" @default.
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- W2062858146 date "2004-02-15" @default.
- W2062858146 modified "2023-10-18" @default.
- W2062858146 title "A Temperature-Sensitive Mutation in the <i>dnaE</i> Gene of <i>Caulobacter crescentus</i> That Prevents Initiation of DNA Replication but Not Ongoing Elongation of DNA" @default.
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- W2062858146 doi "https://doi.org/10.1128/jb.186.4.1205-1212.2004" @default.
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