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- W2062862212 abstract "Cholesterol, long-chain fatty acids, and fat-soluble vitamins are absorbed mainly in the upper small intestine and bile acids in the terminal ileum. This study determined the consequences of ileal autotransplantation on cholesterol metabolism, plasma fatty acids, and vitamin A absorption.Plasma lipids, cholesterol precursors, plant sterols, cholestanol, fatty acids, vitamin A absorption, and animal growth were studied for 3 months after transection (n = 5), jejunal (50%) resection (n = 7), jejunal (50%) resection combined with orthotopic ileal autotransplantation (n = 7), and enterectomy (n = 7).Cholesterol precursor to cholesterol proportions in plasma (reflect cholesterol synthesis) remained unchanged after transection and jejunal resection. The plasma plant sterol proportions (reflect cholesterol absorption) and retinol absorption increased after transection and less significantly after jejunal resection, whereas plasma fatty acid compositions were virtually unchanged. Transplantation of ileum and enterectomy amended up to sixfold the precursor proportions (p < 0.05 versus transection or jejunal resection) and impaired body weight gain. The plant sterol proportions, vitamin A absorption, and plasma cholesterol levels, respectively, were significantly (p < 0.05) decreased after transplantation when compared with those of the transected control group but remained markedly higher than those in the enterectomized group. Linoleic acid was significantly (p < 0.05 versus transection) decreased, whereas monoenoic fatty acids and eicosatrienoic acid were increased (p < 0.05 versus jejunal resection) in plasma lipids.These results indicate that autotransplantation of ileum in pigs that have undergone jejunectomy impairs sterol, essential fatty acid, and vitamin A absorption so that plasma cholesterol levels decrease despite markedly increased cholesterol synthesis and that these changes clearly exceed those found after jejunal resection alone." @default.
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- W2062862212 date "1996-11-01" @default.
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- W2062862212 title "Cholesterol absorption and synthesis after autotransplantation of porcine ileum" @default.
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- W2062862212 doi "https://doi.org/10.1016/s0039-6060(96)80090-0" @default.
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