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• W2062875322 abstract "Histamine H1 receptors in the living human brain were visualized by positron emission tomography (PET) using [N-11C-methyl]-(E)-doxepin([11C]doxepin). The regional distribution of the carbon-11-labeled compound in the brain corresponded well with that of the histamine H1 receptors measured in vitro using [3H]pyrilamine. The radioactivity in the brain was significantly reduced by intravenous pretreatment with d-chlorpheniramine (5 mg). a histamine H1 antagonist. The regional distribution of [11C]doxepin in the brain 45–90 min after its injection was almost the same as that of [11C]pyrilamine in the brain. These results indicate that [11C]doxepin is useful for measuring histamine H1 receptors in human brain by PET." @default.
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• W2062875322 date "1992-03-01" @default.
• W2062875322 modified "2023-10-13" @default.
• W2062875322 title "Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography" @default.
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• W2062875322 doi "https://doi.org/10.1016/0304-3940(92)90390-s" @default.
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