Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062878930> ?p ?o ?g. }
- W2062878930 endingPage "73" @default.
- W2062878930 startingPage "67" @default.
- W2062878930 abstract "Monocrotophos (MCP) is a highly toxic organophosphorus pesticide that has been banned in many countries. Both vitellogenin mRNA expression and secretion were significantly induced in male goldfish by exposure to an MCP-based pesticide, suggesting that MCP has significant estrogenic properties. To elucidate the mechanisms of action of MCP on vitellogenin induction, we used radioimmunoassay to examine the effect of MCP treatment on plasma 17beta-estradiol and testosterone levels in male goldfish (Carassius auratus). We also investigated the potential impacts of MCP treatment on aromatase expression, on the synthesis and secretion of pituitary gonadotropins and on the regulation of hypothalamic gonadotropin-releasing hormones by real-time PCR and radioimmunoassay. Experiments were carried out during the period of gonadal late recrudescence following a 21-day exposure to 0.01, 0.10 and 1.00 mg L(-1) of a pesticide containing 40% MCP in a semi-static exposure system. The results indicated that males in each MCP treatment group had much higher plasma levels of 17beta-estradiol, suggesting that the induction of VTG production by MCP was indirectly caused by elevated levels of endogenous 17beta-estradiol. MCP-induced plasma 17beta-estradiol levels via interference with the reproductive axis at multiple potential sites in male goldfish: (a) MCP exposure enhanced the mRNA expression of gonadal aromatase, the enzyme that converts androgens into estrogens, consequently reducing plasma levels of testosterone and increasing plasma concentrations of 17beta-estradiol; (b) MCP treatment increased follicle-stimulating hormone beta subunit mRNA expression and protein secretion and decreased luteinizing hormone beta subunit mRNA expression and protein secretion, thus interfering with gonadotropin synthesis and secretion at the pituitary level and leading to the disruption of reproductive endocrine control and androgen and estrogen balance." @default.
- W2062878930 created "2016-06-24" @default.
- W2062878930 creator A5028552092 @default.
- W2062878930 creator A5046597133 @default.
- W2062878930 creator A5048586536 @default.
- W2062878930 creator A5085098106 @default.
- W2062878930 date "2010-06-01" @default.
- W2062878930 modified "2023-09-23" @default.
- W2062878930 title "Effects of monocrotophos on the reproductive axis in the male goldfish (Carassius auratus): Potential mechanisms underlying vitellogenin induction" @default.
- W2062878930 cites W1534403844 @default.
- W2062878930 cites W1968117257 @default.
- W2062878930 cites W1968987385 @default.
- W2062878930 cites W1975909673 @default.
- W2062878930 cites W1979560009 @default.
- W2062878930 cites W1985289151 @default.
- W2062878930 cites W1995487921 @default.
- W2062878930 cites W1997897179 @default.
- W2062878930 cites W1999715044 @default.
- W2062878930 cites W2001347231 @default.
- W2062878930 cites W2002448184 @default.
- W2062878930 cites W2007499818 @default.
- W2062878930 cites W2007727039 @default.
- W2062878930 cites W2010181904 @default.
- W2062878930 cites W2013951942 @default.
- W2062878930 cites W2019145251 @default.
- W2062878930 cites W2021277982 @default.
- W2062878930 cites W2022967791 @default.
- W2062878930 cites W2025605433 @default.
- W2062878930 cites W2027781673 @default.
- W2062878930 cites W2032466162 @default.
- W2062878930 cites W2035317503 @default.
- W2062878930 cites W2036443211 @default.
- W2062878930 cites W2039699824 @default.
- W2062878930 cites W2052435478 @default.
- W2062878930 cites W2060818508 @default.
- W2062878930 cites W2061930043 @default.
- W2062878930 cites W2065358032 @default.
- W2062878930 cites W2065605293 @default.
- W2062878930 cites W2072923698 @default.
- W2062878930 cites W2073876098 @default.
- W2062878930 cites W2075956187 @default.
- W2062878930 cites W2087267734 @default.
- W2062878930 cites W2087976173 @default.
- W2062878930 cites W2092920707 @default.
- W2062878930 cites W2096093276 @default.
- W2062878930 cites W2099519823 @default.
- W2062878930 cites W2101512112 @default.
- W2062878930 cites W2103299597 @default.
- W2062878930 cites W2103835764 @default.
- W2062878930 cites W2107250606 @default.
- W2062878930 cites W2111793807 @default.
- W2062878930 cites W2119297098 @default.
- W2062878930 cites W2151565779 @default.
- W2062878930 cites W2157262077 @default.
- W2062878930 cites W2159916899 @default.
- W2062878930 cites W2199385334 @default.
- W2062878930 cites W330718039 @default.
- W2062878930 cites W4244320514 @default.
- W2062878930 cites W4253601422 @default.
- W2062878930 doi "https://doi.org/10.1016/j.aquatox.2010.01.011" @default.
- W2062878930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20149464" @default.
- W2062878930 hasPublicationYear "2010" @default.
- W2062878930 type Work @default.
- W2062878930 sameAs 2062878930 @default.
- W2062878930 citedByCount "28" @default.
- W2062878930 countsByYear W20628789302012 @default.
- W2062878930 countsByYear W20628789302013 @default.
- W2062878930 countsByYear W20628789302014 @default.
- W2062878930 countsByYear W20628789302015 @default.
- W2062878930 countsByYear W20628789302016 @default.
- W2062878930 countsByYear W20628789302017 @default.
- W2062878930 countsByYear W20628789302018 @default.
- W2062878930 countsByYear W20628789302019 @default.
- W2062878930 countsByYear W20628789302021 @default.
- W2062878930 countsByYear W20628789302022 @default.
- W2062878930 crossrefType "journal-article" @default.
- W2062878930 hasAuthorship W2062878930A5028552092 @default.
- W2062878930 hasAuthorship W2062878930A5046597133 @default.
- W2062878930 hasAuthorship W2062878930A5048586536 @default.
- W2062878930 hasAuthorship W2062878930A5085098106 @default.
- W2062878930 hasConcept C104317684 @default.
- W2062878930 hasConcept C121608353 @default.
- W2062878930 hasConcept C126322002 @default.
- W2062878930 hasConcept C134018914 @default.
- W2062878930 hasConcept C161176658 @default.
- W2062878930 hasConcept C176685330 @default.
- W2062878930 hasConcept C2776166826 @default.
- W2062878930 hasConcept C2777164284 @default.
- W2062878930 hasConcept C2778403829 @default.
- W2062878930 hasConcept C2778575703 @default.
- W2062878930 hasConcept C2779078696 @default.
- W2062878930 hasConcept C2779279165 @default.
- W2062878930 hasConcept C2779279991 @default.
- W2062878930 hasConcept C530470458 @default.
- W2062878930 hasConcept C55493867 @default.
- W2062878930 hasConcept C6557445 @default.
- W2062878930 hasConcept C71315377 @default.
- W2062878930 hasConcept C71924100 @default.