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• W2062885122 abstract "ABSTRACT. Leishmania tropica promastigotes transport α-aminoisobutyric acid (AIB), the nonmetabolizable analog of neutral amino acids, against a substantial concentration gradient. AIB is not incorporated into cellular material but accumulates within the cells in an unaltered form. Intracellular AIB exchanges with external AIB. Various energy inhibitors (amytal, HOQNO, KCN, DNP, CCCP, and arsenate) and sulfhydryl reagents (NEM, pCMB, and iodoacetate) severely inhibit uptake. The uptake system is saturable with reference to AIB-and the Lineweaver-Burk plots show biphasic kinetics suggesting the involvement of two transport systems. AIB shares a common transport system with alanine, cysteine, glycine, methionine, serine, and proline. Uptake is regulated by feedback inhibition and transinhibition." @default.
• W2062885122 created "2016-06-24" @default.
• W2062885122 creator A5037345855 @default.
• W2062885122 creator A5082484069 @default.
• W2062885122 date "1983-02-01" @default.
• W2062885122 modified "2023-09-25" @default.
• W2062885122 title "Characteristics of an Uptake System for α-Aminoisobutyric Acid inLeishmania tropicaPromastigotes1" @default.
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• W2062885122 doi "https://doi.org/10.1111/j.1550-7408.1983.tb01030.x" @default.
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