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• W2062885653 abstract "Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events. Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events. a 5′-proximal part of a gRNA that facilitates the formation of a gRNA:mRNA duplex by hybridizing to a mRNA that is to undergo editing. repeat motifs initially described from the Drosophila Armadillo protein and four cytoplasmic proteins in mammals and yeast, respectively, which often act in protein–protein interactions. a stretch of sequence on an edited mRNA that contains several ESs, as determined by the information domain of a gRNA. cleavage site on a mRNA where either a uridine insertion or deletion takes place, as defined by the first base-pair mismatch on the mRNA;gRNA duplex. transcripts in which all the needed editing steps have been completed. small RNAs that act in trans to supply sequence information for decrypting edited mRNAs (one gRNA contained in the 3′-UTR of the coxII mRNA acts in cis). the part of the gRNA that dictates the ESs along an editing block on an edited mRNA; the fully processed editing block is complementary to the anchor domain via normal and non-canonical Watson–Crick base-pairing. the approximately 22 Kb component of kDNA that encodes mRNA and rRNA genes; there are tens of copies of these DNAs, and the gene-encoding region is homogenous in sequence. the approximately 1 Kb component making up the bulk of kDNA encoding gRNA genes; the thousands of copies are heterogeneous in sequence because they represent all the gRNAs needed to decrypt edited mRNAs. transcripts that require kRNA editing only in a small portion of their sequence requiring few gRNAs; sometime also termed moderately-edited. transcripts that forgo kRNA editing. transcripts that undergo kRNA editing throughout their sequence and require many gRNAs. intermediates of pan-edited transcripts undergoing kRNA editing, in which the 5′-proximal sequence remains ‘pre-edited’ whereas the 3′-proximal sequence is ‘edited’. edited transcripts before they undergo kRNA editing, thus having the same sequence as the kDNA maxicircle cryptogene; also termed unedited." @default.
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• W2062885653 date "2013-02-01" @default.
• W2062885653 modified "2023-10-18" @default.
• W2062885653 title "Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex" @default.
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• W2062885653 doi "https://doi.org/10.1016/j.pt.2012.11.005" @default.
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