Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062896874> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2062896874 endingPage "83" @default.
- W2062896874 startingPage "75" @default.
- W2062896874 abstract "Using methods for cell lysis and fractionation which yield essentially quantitative recovery of rat prostate cancer cell cytosolic and nuclear androgen receptors, we examined androgen modulation of androgen receptor content of clonally derived prostate cancer cell lines. We showed that testosterone elicited a concentration-dependent 2.3-fold increase in T5 cell androgen receptor content which was maximum after 48 h and was maintained through at least 72 h of culture. Testosterone caused only a 1.4-fold elevation in D2 cell androgen receptor content which was maximum between 6 and 12 h of culture and was maintained through at least 72 h culture. In contrast, testosterone did not cause a change in C3 cell androgen receptor content. Cycloheximide inhibition showed that both the testosterone-mediated increase in and maintenance of basal prostate cancer cell androgen receptor content required protein synthesis. Because testosterone and the nonmetabolizable androgen R1881 were essentially equipotent as effectors of the increase in T5 cell androgen receptor content, findings using testosterone appear to represent maximum effects. RU 23908 antagonized both R1881 and testosterone promoted elevations of prostate cancer cell androgen receptor content. Effectiveness of RU 23908 was comparable to the relative binding affinity of R1881, testosterone and RU 23908 for androgen receptors. This implies that at least part of the androgen-promoted increase in prostate cancer cell androgen receptor content is mediated through the action of androgen receptors and suggests that androgen receptors may act as both cis and trans regulatory elements. The mechanisms which determine basal or androgen-modulated prostate cancer cell androgen receptor content remain to be elucidated." @default.
- W2062896874 created "2016-06-24" @default.
- W2062896874 creator A5031481078 @default.
- W2062896874 creator A5047702767 @default.
- W2062896874 date "1989-05-01" @default.
- W2062896874 modified "2023-09-25" @default.
- W2062896874 title "Androgen modulation of prostate cancer cell androgen receptor content is cell line specific" @default.
- W2062896874 cites W1509410528 @default.
- W2062896874 cites W1582959126 @default.
- W2062896874 cites W1965283193 @default.
- W2062896874 cites W1967362637 @default.
- W2062896874 cites W1969369593 @default.
- W2062896874 cites W1983649348 @default.
- W2062896874 cites W1987216276 @default.
- W2062896874 cites W1990926131 @default.
- W2062896874 cites W1997556810 @default.
- W2062896874 cites W1999669752 @default.
- W2062896874 cites W2017211490 @default.
- W2062896874 cites W2043844290 @default.
- W2062896874 cites W2046171537 @default.
- W2062896874 cites W2050602600 @default.
- W2062896874 cites W2054706881 @default.
- W2062896874 cites W2069982763 @default.
- W2062896874 cites W2072341013 @default.
- W2062896874 cites W2074013684 @default.
- W2062896874 cites W2104360623 @default.
- W2062896874 cites W2144983116 @default.
- W2062896874 cites W2147952647 @default.
- W2062896874 cites W2162588777 @default.
- W2062896874 cites W62080596 @default.
- W2062896874 doi "https://doi.org/10.1016/0303-7207(89)90083-x" @default.
- W2062896874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2787764" @default.
- W2062896874 hasPublicationYear "1989" @default.
- W2062896874 type Work @default.
- W2062896874 sameAs 2062896874 @default.
- W2062896874 citedByCount "9" @default.
- W2062896874 countsByYear W20628968742018 @default.
- W2062896874 crossrefType "journal-article" @default.
- W2062896874 hasAuthorship W2062896874A5031481078 @default.
- W2062896874 hasAuthorship W2062896874A5047702767 @default.
- W2062896874 hasConcept C121608353 @default.
- W2062896874 hasConcept C126322002 @default.
- W2062896874 hasConcept C134018914 @default.
- W2062896874 hasConcept C170493617 @default.
- W2062896874 hasConcept C185592680 @default.
- W2062896874 hasConcept C2777911890 @default.
- W2062896874 hasConcept C2779279991 @default.
- W2062896874 hasConcept C2780192828 @default.
- W2062896874 hasConcept C61367390 @default.
- W2062896874 hasConcept C71315377 @default.
- W2062896874 hasConcept C71924100 @default.
- W2062896874 hasConcept C86803240 @default.
- W2062896874 hasConceptScore W2062896874C121608353 @default.
- W2062896874 hasConceptScore W2062896874C126322002 @default.
- W2062896874 hasConceptScore W2062896874C134018914 @default.
- W2062896874 hasConceptScore W2062896874C170493617 @default.
- W2062896874 hasConceptScore W2062896874C185592680 @default.
- W2062896874 hasConceptScore W2062896874C2777911890 @default.
- W2062896874 hasConceptScore W2062896874C2779279991 @default.
- W2062896874 hasConceptScore W2062896874C2780192828 @default.
- W2062896874 hasConceptScore W2062896874C61367390 @default.
- W2062896874 hasConceptScore W2062896874C71315377 @default.
- W2062896874 hasConceptScore W2062896874C71924100 @default.
- W2062896874 hasConceptScore W2062896874C86803240 @default.
- W2062896874 hasIssue "1-2" @default.
- W2062896874 hasLocation W20628968741 @default.
- W2062896874 hasLocation W20628968742 @default.
- W2062896874 hasOpenAccess W2062896874 @default.
- W2062896874 hasPrimaryLocation W20628968741 @default.
- W2062896874 hasRelatedWork W1950049800 @default.
- W2062896874 hasRelatedWork W1981433740 @default.
- W2062896874 hasRelatedWork W2004261902 @default.
- W2062896874 hasRelatedWork W2011296913 @default.
- W2062896874 hasRelatedWork W2014027373 @default.
- W2062896874 hasRelatedWork W2053954521 @default.
- W2062896874 hasRelatedWork W2059176014 @default.
- W2062896874 hasRelatedWork W2168538548 @default.
- W2062896874 hasRelatedWork W2908463329 @default.
- W2062896874 hasRelatedWork W2052423078 @default.
- W2062896874 hasVolume "63" @default.
- W2062896874 isParatext "false" @default.
- W2062896874 isRetracted "false" @default.
- W2062896874 magId "2062896874" @default.
- W2062896874 workType "article" @default.