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- W2062899765 abstract "Airway tissue shows unexpected invulnerability to heated air. The mechanisms of this phenomenon are open to debate. This study was designed to measure the surface temperatures at different locations of the airway, and to explore the relationship between the tissue's surface temperature and injury severity. Twenty dogs were randomly divided into four groups, including three experimental groups (six dogs in each) to inhale heated air at 70–80 °C (group I), 150–160 °C (group II) and 310–320 °C (group III) and a control group (two dogs, only for histological observation). Injury time was 20 min. Mucosal surface temperatures of the epiglottis (point A), cricoid cartilage (point B) and lower trachea (point C) were measured. Dogs in group I–III were divided into three subgroups (two in each), to be assayed at 12, 24 and 36 h after injury, respectively. For each dog, four tissue parts (epiglottis, larynx, lower trachea and terminal bronchiole) were microscopically observed and graded according to an original pathological scoring system (score range: 0–27). Surface temperatures of the airway mucosa increased slowly to 40.60 ± 3.29 °C, and the highest peak temperature was 48.3 °C (group III, point A). The pathological score of burned tissues was 4.12 ± 4.94 (0.0–18.0), suggesting slight to moderate injuries. Air temperature and airway location both influenced mucosal temperature and pathological scores very significantly, and there was a very significant positive correlation between tissue temperature and injury severity. Compared to the inhalational air hyperthermia, airway surface temperature was much lower, but was still positively correlated with thermal injury severity." @default.
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- W2062899765 date "2013-06-01" @default.
- W2062899765 modified "2023-09-25" @default.
- W2062899765 title "Measuring surface temperature and grading pathological changes of airway tissue in a canine model of inhalational thermal injury" @default.
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- W2062899765 doi "https://doi.org/10.1016/j.burns.2012.10.024" @default.
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