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• W2062904343 abstract "<h3>Abstract</h3> <b>Objective</b>: To examine the dose-response effect of alcohol consumption on the number of cerebellar Purkinje cells. <b>Design</b>: A prospective necropsy study combined with detailed reports on use of alcohol from a relative or friend. The number of Purkinje cells was counted in the anterior midsagittal section of the cerebellar vermis, the area of which was measured by computer assisted morphometry. <b>Setting</b>: Department of forensic medicine, University of Helsinki. <b>Subjects</b>: 66 men, aged 35 to 69 years, subjected to medicolegal necropsy because of sudden or violent death. The average all year daily alcohol consumption over the year was 0 to 10 g in 17 men, 11 to 80 g in 24 men, and more than 80 g in 25 men. <b>Main outcome measures</b>: Number of Purkinje cells, alcohol consumption. <b>Results</b>: The number of density of Purkinje cells in the cross section of vermis showed a consistent but weak decrease with increasing daily alcohol intake but not with age. A wide variation in the cell counts was observed, especially in men drinking more than 80 g, suggesting differences in the susceptibility to effects of alcohol. Compared with men drinking 40 g or less, a long term moderate consumption of an average of 41 to 80 g daily was associated with a significant average loss of 242 (95% confidence interval 45 to 439) Purkinje cells (15.2%) from a mean of 1583 to 1341 cells. In those drinking 81 to 180 g the average loss was 535 (259 to20811) cells (33.4%) to a mean of 1048 cells. The density of cells in the cross section of vermis also fell significantly by 0.9 cell/mm (0.1 to 1.7) when the daily consumption exceeded 40 g and by 1.4 cell/mm (0.3 to 2.5) when the intake was 81 to 180 g. Only three cases (4.5%) in the series showed macroscopical cerebellar atrophy. <b>Conclusion</b>: Long term intake of moderate doses of alcohol daily for 20- 30 years may damage the cerebellum before the onset of macroscopical atrophy. Despite distinct individual differences an all year average daily alcohol intake of 41-80 g results in a risk of significant loss of Purkinje cells." @default.
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• W2062904343 date "1994-06-25" @default.
• W2062904343 modified "2023-09-27" @default.
• W2062904343 title "Moderate alcohol consumption and loss of cerebellar Prikinje cells" @default.
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• W2062904343 doi "https://doi.org/10.1136/bmj.308.6945.1663" @default.
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