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- W2062915265 abstract "8-DL-Homolysine-vasopressin and its 1-deamino derivative were synthesized by the solid phase method. The desired D-homolysine analogues were obtained by digestion of the mixtures with trypsin and isolation of the peptide components by ion-exchange chromatography. In agreement with earlier observations on vasopressins containing alpha, omega-diamino acids of D configuration the new analogues show very low pressor activities. However, the antidiuretic effects are surprisingly high, thus reversing the known activity trend and making the D-homolysine analogues highly selective antidiuretic agents." @default.
- W2062915265 created "2016-06-24" @default.
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- W2062915265 date "2009-01-12" @default.
- W2062915265 modified "2023-09-27" @default.
- W2062915265 title "SOLID PHASE SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 8-D-HOMOLYSINE-VASOPRESSIN AND 1-DEAMINO-8-D-HOMOLYSINE-VASOPRESSIN" @default.
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- W2062915265 doi "https://doi.org/10.1111/j.1399-3011.1975.tb02458.x" @default.
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