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• W2062918366 abstract "W.H.A.M. Mulders, M.J. West, and L. Slomianka (1997) Neuron numbers in the presubiculum, parasubiculum, and entorhinal area of the rat. J. Comp. Neurol. 385:83–94. We have recently identified an error in our procedures used to estimate the number of neurons in the layers of the human entorhinal cortex, which resulted in an overestimation of cell numbers by a factor of 1.66 (for details see Erratum to West and Slomianka, 1998). The corrected human entorhinal cell numbers are similar to those reported by Gómez-Isla et al. (1996) and compatible with estimates presented by Krimer et al. (1997). This error does not affect the data presented in our paper concerning the rat entorhinal cortex or those parts of the discussion relating to quantitative relationship within the rat hippocampal region. It does however have a significant impact on our discussion of possible differences in quantitative relationships in humans and rats. We concluded in our paper that the ratios of the numbers of cells in interconnected cell layers were similar in rats and humans. Table 1, which presents these ratios based on the corrected cell numbers in the human entorhinal cortex, illustrates that this interpretation is no longer tenable. The corrected data indicate clear differences in the degree of divergence of projections from entorhinal to hippocampal cells layers and in the degree of convergence of hippocampal projections to entorhinal cells layers. Following one of the lines of argument in our paper, it is likely that the degree of convergence of projections from CA1 to layer V of the entorhinal cortex is least affected by these changes (instead of being the only example of a different degree of convergence or divergence between the two species). Consequently, models of hippocampal function that incorporate neuron numbers determined in the rat can not a priori be expected to be appropriate representations of hippocampal function in humans. Gómez-Isla, T., J.L. Price, D.W. McKeel, Jr., J.C. Morris, J.H. Growdon, and B.T. Hyman (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 16:4491–4500. Krimer, L.S., M.M. Herman, R.C. Saunders, J.C. Boyd, T.M. Hyde, J.M. Carter, J.E. Kleinman, and D.R. Weinberger (1997) A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia. Cereb. Cortex 7:732–739. West, M.J. and L. Slomainka (1998) Total number of neurons in the layers of the human entorhinal cortex. Hippocampus 8:69–82 and Corrigendum (1998) Hippocampus, 8:426." @default.
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• W2062918366 title "Neuron numbers in the presubiculum, parasubiculum, and entorhinal area of the rat. J. Comp. Neurol.385:83-94" @default.
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