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• W2062923632 abstract "Alkylating agents have been shown to be very promising for the radiolabelling of oligonucleotides with fluorine-18. In this report we describe the fully automated synthesis of 2-bromo-N-[3-(2-[(18)F]fluoropyridin-3-yloxy)propyl]acetamide ([(18)F]FPyBrA) utilizing a modular synthesis unit. Reaction conditions for the coupling of this pyridine-based alkylating agent at the 5' end of a fully phosphorothioated random 20-mer DNA sequence were optimized to achieve very high radiochemical yields (>90%) and a maximum specific activity of 5-6 GBq/micromoL. The potential for rapid purification by solid phase extraction without need of chromatographic isolation of the radiolabelled oligonucleotide presents an overall benefit for the application of oligonucleotides in preclinical studies and potential clinical applications." @default.
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• W2062923632 date "2009-09-01" @default.
• W2062923632 modified "2023-09-25" @default.
• W2062923632 title "Automated synthesis of an 18F-labelled pyridine-based alkylating agent for high yield oligonucleotide conjugation" @default.
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• W2062923632 doi "https://doi.org/10.1016/j.apradiso.2009.04.004" @default.
• W2062923632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3087498" @default.
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