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- W2062937295 abstract "Strains of mice differ greatly in their capacity to produce interleukin (IL) 4 and high levels of serum IgE. The contribution of macrophages (Mϕ) in enhancing the production of IL 4 by T cells in high-IgE responder mice was studied. Mϕ from BALB/c mice (high-IgE responder strain) developed an augmented capacity to present antigen to IL 4-producing T helper type 2 (Th2) clones, when the Mϕ were pretreated by exposure to the lymphokines IL 4 and IL 5. In contrast, identical treatment of Mϕ from H-2-identical DBA/2 mice (low-IgE responder strain) resulted in inhibition of the capacity to stimulate Th2 clones. The impairment of antigen presentation by DBA/2 Mϕ was closely paralleled by a decrease of cell surface class II major histocompatibility complex (MHC) expression and an abrogation of IL 1 production by these cells, while identical treatment of BALB/c Mϕ enhanced class II MHC expression and did not inhibit secretion of IL 1. Our studies demonstrate that IL 4 and IL 5 can exert different effects on Mϕ from high- and low-IgE responder strains of mice, resulting in down-regulation of the expansion of IL 4-producing cells in low- but not high-IgE responder mice." @default.
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- W2062937295 date "1991-07-01" @default.
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- W2062937295 title "Differential regulation of antigen presentation in high- and low-IgE responder mice" @default.
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- W2062937295 doi "https://doi.org/10.1002/eji.1830210729" @default.
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