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• W2062963521 abstract "We report the analysis of human nucleotide diversity at a genetic locus known to be involved in a behavioral phenotype, the monoamine oxidase A gene. Sequencing of five regions totaling 18.8 kb and spanning 90 kb of the monoamine oxidase A gene was carried out in 56 male individuals from seven different ethnogeographic groups. We uncovered 41 segregating sites, which formed 46 distinct haplotypes. A permutation test detected substantial population structure in these samples. Consistent with differentiation between populations, linkage disequilibrium is higher than expected under panmixia, with no evidence of a decay with distance. The extent of linkage disequilibrium is not typical of nuclear loci and suggests that the underlying population structure may have been accentuated by a selective sweep that fixed different haplotypes in different populations, or by local adaptation. In support of this suggestion, we find both a reduction in levels of diversity (as measured by a Hudson–Kreitman–Aguade test with the DMD44 locus) and an excess of high frequency-derived variants, as expected after a recent episode of positive selection." @default.
• W2062963521 created "2016-06-24" @default.
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• W2062963521 date "2002-01-22" @default.
• W2062963521 modified "2023-09-24" @default.
• W2062963521 title "Evidence for positive selection and population structure at the human <i>MAO-A</i> gene" @default.
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• W2062963521 doi "https://doi.org/10.1073/pnas.022614799" @default.
• W2062963521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/117396" @default.
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