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- W2062989619 abstract "C34-epi and C34-epi-C35-trifluoro analogues of solamin, a mono-THF annonaceous acetogenin, were synthesized. Their inhibitory activity, along with previously synthesized analogues (C35-fluoro, C35-difluoro, and C35-trifluorosolamins), against bovine mitochondrial NADH-ubiquinone oxidoreductase (complex I) was determined. The present study revealed that the methyl group on the γ-lactone moiety is critical to the potent inhibition of complex I by natural acetogenins." @default.
- W2062989619 created "2016-06-24" @default.
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- W2062989619 date "2013-03-01" @default.
- W2062989619 modified "2023-10-10" @default.
- W2062989619 title "Critical role of a methyl group on the γ-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I" @default.
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- W2062989619 doi "https://doi.org/10.1016/j.bmcl.2013.01.018" @default.
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