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- W2062990140 abstract "Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). Preclinical and open-label studies have suggested that grafted fetal neural tissue or viral vector gene transfer can achieve considerable biochemical and clinical improvements, whereas subsequent double-blind, placebo-controlled protocols have produced rather more modest and variable results. Detailed evaluation of these discordant findings has highlighted several crucial issues such as patient selection criteria, details surrounding transplantation or gene therapy methodologies, as well as the study designs themselves that ought to be carefully considered in the planning phases of future clinical trials. Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS)." @default.
- W2062990140 created "2016-06-24" @default.
- W2062990140 creator A5000414294 @default.
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- W2062990140 creator A5031389008 @default.
- W2062990140 date "2011-01-01" @default.
- W2062990140 modified "2023-09-30" @default.
- W2062990140 title "Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies" @default.
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- W2062990140 cites W1966513242 @default.
- W2062990140 cites W1969644104 @default.
- W2062990140 cites W1971258758 @default.
- W2062990140 cites W1973466789 @default.
- W2062990140 cites W1977376243 @default.
- W2062990140 cites W1983802226 @default.
- W2062990140 cites W1987203624 @default.
- W2062990140 cites W1991208841 @default.
- W2062990140 cites W1996001296 @default.
- W2062990140 cites W1997008745 @default.
- W2062990140 cites W1999702935 @default.
- W2062990140 cites W1999807227 @default.
- W2062990140 cites W2010022442 @default.
- W2062990140 cites W2011234266 @default.
- W2062990140 cites W2011418698 @default.
- W2062990140 cites W2012689648 @default.
- W2062990140 cites W2012770364 @default.
- W2062990140 cites W2013110094 @default.
- W2062990140 cites W2014850190 @default.
- W2062990140 cites W2015500392 @default.
- W2062990140 cites W2017424741 @default.
- W2062990140 cites W2018585440 @default.
- W2062990140 cites W2019935461 @default.
- W2062990140 cites W2021931341 @default.
- W2062990140 cites W2030318177 @default.
- W2062990140 cites W2031584008 @default.
- W2062990140 cites W2035325688 @default.
- W2062990140 cites W2044407202 @default.
- W2062990140 cites W2045733024 @default.
- W2062990140 cites W2046910164 @default.
- W2062990140 cites W2046956342 @default.
- W2062990140 cites W2047517389 @default.
- W2062990140 cites W2049393626 @default.
- W2062990140 cites W2050647292 @default.
- W2062990140 cites W2054399886 @default.
- W2062990140 cites W2054810445 @default.
- W2062990140 cites W2065564530 @default.
- W2062990140 cites W2068575709 @default.
- W2062990140 cites W2079356832 @default.
- W2062990140 cites W2084543881 @default.
- W2062990140 cites W2095270577 @default.
- W2062990140 cites W2095401453 @default.
- W2062990140 cites W2096882342 @default.
- W2062990140 cites W2100049664 @default.
- W2062990140 cites W2101918174 @default.
- W2062990140 cites W2102491127 @default.
- W2062990140 cites W2103612759 @default.
- W2062990140 cites W2103977342 @default.
- W2062990140 cites W2104793567 @default.
- W2062990140 cites W2105688544 @default.
- W2062990140 cites W2106900546 @default.
- W2062990140 cites W2111837903 @default.
- W2062990140 cites W2117875223 @default.
- W2062990140 cites W2118353064 @default.
- W2062990140 cites W2121074272 @default.
- W2062990140 cites W2121087049 @default.
- W2062990140 cites W2125320763 @default.
- W2062990140 cites W2126384757 @default.
- W2062990140 cites W2126499376 @default.
- W2062990140 cites W2130275119 @default.
- W2062990140 cites W2132551489 @default.
- W2062990140 cites W2136018016 @default.
- W2062990140 cites W2136541538 @default.
- W2062990140 cites W2138462240 @default.
- W2062990140 cites W2141355937 @default.
- W2062990140 cites W2149731696 @default.
- W2062990140 cites W2150295951 @default.
- W2062990140 cites W2151497983 @default.
- W2062990140 cites W2156411508 @default.
- W2062990140 cites W2162501437 @default.
- W2062990140 cites W2163987873 @default.
- W2062990140 cites W2164797304 @default.
- W2062990140 cites W2165526364 @default.
- W2062990140 cites W2168341415 @default.
- W2062990140 cites W2177094286 @default.
- W2062990140 cites W2318463768 @default.
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- W2062990140 doi "https://doi.org/10.4061/2011/804041" @default.
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