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- W2062990906 abstract "Purpose of review Ulcerative colitis is a chronic inflammatory disease of the colon of unknown cause that is characterized by alternating intervals of active and inactive disease in 80–90% of patients. The primary goal of treatment is to induce and maintain remission using therapy tailored to the individual patient. The purpose of this review was to describe the management of ulcerative colitis with emphasis on the use of anti-tumor necrosis factor (TNF) agents. Recent findings Recent research has shown that new anti-TNF agents, adalimumab (ADA) and golimumab, are effective in induction of remission and maintenance of remission in patients with extensive ulcerative colitis. In a recent study, infliximab was found to have comparable efficacy to cyclosporine in treatment of acute severe refractory to corticosteroids ulcerative colitis. Summary Anti-TNF therapy should be initiated in patients with acute severe refractory to corticosteroids ulcerative colitis and in patients with moderate-to-severe ulcerative colitis who are not responsive to conventional treatment with aminosalicylates, corticosteroids and immune modulators. Alternatives to infliximab are ADA and golimumab. Future research is needed to further assess the long-term efficacy and safety of ADA and golimumab in ulcerative colitis." @default.
- W2062990906 created "2016-06-24" @default.
- W2062990906 creator A5035191721 @default.
- W2062990906 creator A5044524314 @default.
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- W2062990906 date "2014-01-01" @default.
- W2062990906 modified "2023-09-23" @default.
- W2062990906 title "Treatment of ulcerative colitis" @default.
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- W2062990906 doi "https://doi.org/10.1097/mog.0000000000000031" @default.
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