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- W2063008647 abstract "Covalent modification of Ad vector capsids with synthetic polymers has been proven to aid in overcoming one of the most complex hurdles of Ad vector gene delivery, namely, the innate immune response to the vector particle. Although the observed reduction in innate immune responses induced by polymer-modified vector particles is not complete, it adds significantly to the safety (and therefore to the utility) of Ad vectors. Evaluation of innate immune responses has been conducted in mice. Certainly larger animal models and non-human primates will be required as model systems so as to evaluate the potential of polymer-modified Ad vectors to provide safer gene delivery with decreased risks of adverse events. A remarkable attribute of polymer-modified vectors is their ability to evade pre-existing neutralizing anti-vector antibodies, thereby overcoming another important hurdle, particular for Ad5-based vector systems. In addition, interactions with non-target cellular blood components like platelets and, importantly, macrophages can be reduced by polymer-modification of Ad vectors. Promising targeting and re-targeting strategies have been developed based on this technology. However, during the past few years certain limitations of this technology have become obvious, such as limited alteration of biodistribution after systemic delivery. We have discussed polymer-modifications in detail and proposed directions for future research based on this emerging technology." @default.
- W2063008647 created "2016-06-24" @default.
- W2063008647 creator A5044058894 @default.
- W2063008647 creator A5063055218 @default.
- W2063008647 date "2008-01-01" @default.
- W2063008647 modified "2023-10-15" @default.
- W2063008647 title "Modification of Adenovirus Gene Transfer Vectors With Synthetic Polymers: A Scientific Review and Technical Guide" @default.
- W2063008647 cites W1602020336 @default.
- W2063008647 cites W1967033604 @default.
- W2063008647 cites W1971820715 @default.
- W2063008647 cites W1972258033 @default.
- W2063008647 cites W1973957725 @default.
- W2063008647 cites W1975752974 @default.
- W2063008647 cites W1976594964 @default.
- W2063008647 cites W1976870459 @default.
- W2063008647 cites W1982794080 @default.
- W2063008647 cites W1984183779 @default.
- W2063008647 cites W1984376606 @default.
- W2063008647 cites W1985889861 @default.
- W2063008647 cites W1987723433 @default.
- W2063008647 cites W1989736806 @default.
- W2063008647 cites W1992033402 @default.
- W2063008647 cites W1995291792 @default.
- W2063008647 cites W2008254103 @default.
- W2063008647 cites W2009535263 @default.
- W2063008647 cites W2010609199 @default.
- W2063008647 cites W2011762615 @default.
- W2063008647 cites W2015248839 @default.
- W2063008647 cites W2016200465 @default.
- W2063008647 cites W2016679871 @default.
- W2063008647 cites W2022429082 @default.
- W2063008647 cites W2022668894 @default.
- W2063008647 cites W2025616153 @default.
- W2063008647 cites W2026858501 @default.
- W2063008647 cites W2027980197 @default.
- W2063008647 cites W2036898193 @default.
- W2063008647 cites W2038526143 @default.
- W2063008647 cites W2040837189 @default.
- W2063008647 cites W2041573878 @default.
- W2063008647 cites W2042834453 @default.
- W2063008647 cites W2044527317 @default.
- W2063008647 cites W2046822617 @default.
- W2063008647 cites W2052335602 @default.
- W2063008647 cites W2061448062 @default.
- W2063008647 cites W2063187228 @default.
- W2063008647 cites W2064074518 @default.
- W2063008647 cites W2071448794 @default.
- W2063008647 cites W2072160274 @default.
- W2063008647 cites W2077477657 @default.
- W2063008647 cites W2078051582 @default.
- W2063008647 cites W2079852426 @default.
- W2063008647 cites W2083827148 @default.
- W2063008647 cites W2086456875 @default.
- W2063008647 cites W2090864647 @default.
- W2063008647 cites W2093120959 @default.
- W2063008647 cites W2095418304 @default.
- W2063008647 cites W2095615635 @default.
- W2063008647 cites W2098617460 @default.
- W2063008647 cites W2100808701 @default.
- W2063008647 cites W2102462301 @default.
- W2063008647 cites W2105616717 @default.
- W2063008647 cites W2108860107 @default.
- W2063008647 cites W2114458218 @default.
- W2063008647 cites W2122033091 @default.
- W2063008647 cites W2128958477 @default.
- W2063008647 cites W2131095976 @default.
- W2063008647 cites W2131412865 @default.
- W2063008647 cites W2143945307 @default.
- W2063008647 cites W2144678672 @default.
- W2063008647 cites W2145786098 @default.
- W2063008647 cites W2151902657 @default.
- W2063008647 cites W2154038583 @default.
- W2063008647 cites W2154853039 @default.
- W2063008647 cites W2156119419 @default.
- W2063008647 cites W2156492800 @default.
- W2063008647 cites W2156829792 @default.
- W2063008647 cites W2162611042 @default.
- W2063008647 cites W2163192616 @default.
- W2063008647 cites W2163708786 @default.
- W2063008647 cites W2164806280 @default.
- W2063008647 cites W2175655302 @default.
- W2063008647 cites W2258579604 @default.
- W2063008647 cites W2316543256 @default.
- W2063008647 cites W2316811173 @default.
- W2063008647 cites W2322606593 @default.
- W2063008647 doi "https://doi.org/10.1038/sj.mt.6300321" @default.
- W2063008647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17912234" @default.
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