FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063011510> ?p ?o ?g. }

• W2063011510 endingPage "209" @default.
• W2063011510 startingPage "202" @default.
• W2063011510 abstract "Circumstantial evidence suggests that Propionibacterium acnes has a role in the inflammation of acne. This could be effected by antigenic or superantigenic or mitogenic reactions.The purpose of this investigation was to determine whether P. acnes had only antigenic activity or additional superantigenic and mitogenic activity.A lymphocyte transformation assay was used to detect responses to a mixture of eight P. acnes whole cell isolates, and their supernatant culture fluids. In order to determine the nature of T-cell reactions to P. acnes cells a mouse-antihuman major histocompatibility complex class II monoclonal antibody was used in the lymphocyte transformation assay to inhibit the antigenic stimulation of lymphocytes. An analysis of the T-cell receptor (TCR) variable region beta (BV) repertoire was undertaken using flow cytometry of the unstimulated and stimulated cells.Peripheral blood mononuclear cells (PBMNC) from adults with no history of acne responded strongly to stationary growth phase cells of P. acnes, less strongly to cells in the exponential growth phase. No response was detected to supernatant culture fluids. PBMNC from five cord blood samples (CBMNC) responded maximally after 3 and 7 days of incubation with stationary growth phase cells of P. acnes. The reaction of CBMNC to P. acnes cells was not suppressed completely by the blocking antibody. The analysis of the TCRBV repertoire indicated that P. acnes induced no deletion or over-representation of certain BV element-bearing T cells. The TCRBV analysis was repeated after preincubation with the blocking antibody. Deletion of T cells bearing certain BV components occurred and there was no over-representation of T cells carrying certain BV components.Two mechanisms of lymphocyte activation by P. acnes cells are proposed, antigen and mitogen driven. These results are consistent with the histological evidence of inflammation in acne lesions." @default.
• W2063011510 created "2016-06-24" @default.
• W2063011510 creator A5050476353 @default.
• W2063011510 creator A5053725151 @default.
• W2063011510 creator A5054685828 @default.
• W2063011510 creator A5066390295 @default.
• W2063011510 date "2002-02-01" @default.
• W2063011510 modified "2023-10-12" @default.
• W2063011510 title "Propionibacterium acnes and inflammation in acne; P. acnes has T-cell mitogenic activity" @default.
• W2063011510 cites W1496782251 @default.
• W2063011510 cites W1972456228 @default.
• W2063011510 cites W2015831529 @default.
• W2063011510 cites W2023298860 @default.
• W2063011510 cites W2034082487 @default.
• W2063011510 cites W2051461560 @default.
• W2063011510 cites W2055133589 @default.
• W2063011510 cites W2057947313 @default.
• W2063011510 cites W2062086068 @default.
• W2063011510 cites W2075351979 @default.
• W2063011510 cites W2089007051 @default.
• W2063011510 cites W2096878303 @default.
• W2063011510 cites W2097303534 @default.
• W2063011510 cites W2106008126 @default.
• W2063011510 cites W2112151566 @default.
• W2063011510 cites W2115435268 @default.
• W2063011510 cites W2270536249 @default.
• W2063011510 cites W2322738151 @default.
• W2063011510 cites W2409445055 @default.
• W2063011510 cites W4232534952 @default.
• W2063011510 doi "https://doi.org/10.1046/j.1365-2133.2002.04602.x" @default.
• W2063011510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11903228" @default.
• W2063011510 hasPublicationYear "2002" @default.
• W2063011510 type Work @default.
• W2063011510 sameAs 2063011510 @default.
• W2063011510 citedByCount "76" @default.
• W2063011510 countsByYear W20630115102012 @default.
• W2063011510 countsByYear W20630115102013 @default.
• W2063011510 countsByYear W20630115102014 @default.
• W2063011510 countsByYear W20630115102015 @default.
• W2063011510 countsByYear W20630115102016 @default.
• W2063011510 countsByYear W20630115102017 @default.
• W2063011510 countsByYear W20630115102018 @default.
• W2063011510 countsByYear W20630115102019 @default.
• W2063011510 countsByYear W20630115102020 @default.
• W2063011510 countsByYear W20630115102021 @default.
• W2063011510 countsByYear W20630115102023 @default.
• W2063011510 crossrefType "journal-article" @default.
• W2063011510 hasAuthorship W2063011510A5050476353 @default.
• W2063011510 hasAuthorship W2063011510A5053725151 @default.
• W2063011510 hasAuthorship W2063011510A5054685828 @default.
• W2063011510 hasAuthorship W2063011510A5066390295 @default.
• W2063011510 hasConcept C137061746 @default.
• W2063011510 hasConcept C147483822 @default.
• W2063011510 hasConcept C153911025 @default.
• W2063011510 hasConcept C159654299 @default.
• W2063011510 hasConcept C19317047 @default.
• W2063011510 hasConcept C202751555 @default.
• W2063011510 hasConcept C203014093 @default.
• W2063011510 hasConcept C2776090121 @default.
• W2063011510 hasConcept C2777673923 @default.
• W2063011510 hasConcept C2779900937 @default.
• W2063011510 hasConcept C2992881475 @default.
• W2063011510 hasConcept C36333154 @default.
• W2063011510 hasConcept C54355233 @default.
• W2063011510 hasConcept C55493867 @default.
• W2063011510 hasConcept C86803240 @default.
• W2063011510 hasConcept C8891405 @default.
• W2063011510 hasConcept C89423630 @default.
• W2063011510 hasConceptScore W2063011510C137061746 @default.
• W2063011510 hasConceptScore W2063011510C147483822 @default.
• W2063011510 hasConceptScore W2063011510C153911025 @default.
• W2063011510 hasConceptScore W2063011510C159654299 @default.
• W2063011510 hasConceptScore W2063011510C19317047 @default.
• W2063011510 hasConceptScore W2063011510C202751555 @default.
• W2063011510 hasConceptScore W2063011510C203014093 @default.
• W2063011510 hasConceptScore W2063011510C2776090121 @default.
• W2063011510 hasConceptScore W2063011510C2777673923 @default.
• W2063011510 hasConceptScore W2063011510C2779900937 @default.
• W2063011510 hasConceptScore W2063011510C2992881475 @default.
• W2063011510 hasConceptScore W2063011510C36333154 @default.
• W2063011510 hasConceptScore W2063011510C54355233 @default.
• W2063011510 hasConceptScore W2063011510C55493867 @default.
• W2063011510 hasConceptScore W2063011510C86803240 @default.
• W2063011510 hasConceptScore W2063011510C8891405 @default.
• W2063011510 hasConceptScore W2063011510C89423630 @default.
• W2063011510 hasIssue "2" @default.
• W2063011510 hasLocation W20630115101 @default.
• W2063011510 hasLocation W20630115102 @default.
• W2063011510 hasOpenAccess W2063011510 @default.
• W2063011510 hasPrimaryLocation W20630115101 @default.
• W2063011510 hasRelatedWork W1483536410 @default.
• W2063011510 hasRelatedWork W1545383778 @default.
• W2063011510 hasRelatedWork W1559347919 @default.
• W2063011510 hasRelatedWork W1966653295 @default.
• W2063011510 hasRelatedWork W2015361131 @default.
• W2063011510 hasRelatedWork W2044682925 @default.
• W2063011510 hasRelatedWork W2045725086 @default.
• W2063011510 hasRelatedWork W2166897865 @default.

• next