FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063012807> ?p ?o ?g. }

• W2063012807 endingPage "31" @default.
• W2063012807 startingPage "25" @default.
• W2063012807 abstract "The N-linked oligosaccharides on human choriogonadotropin (hCG) and follitropin (hFSH) alpha-subunit loop 2 (alpha2) have a dominant influence on hormone efficacy. hCG analogs lacking this oligosaccharide retain approximately 40% the efficacy of the fully glycosylated hormone in cyclic AMP accumulation assays. Previous efforts to reduce efficacy further have involved removing the other N-linked oligosaccharides. We found that some intersubunit disulfide crosslinks reduced the efficacies of hCG analogs lacking only the alpha2 oligosaccharide. The least active analog was an hCG/hFSH chimera containing hFSH residues 95-108 in place of hCG residues 101-114 and a disulfide bond between alpha-subunit residue 37 and beta-subunit residue 33. While it bound lutropin receptors 2- to 3-fold better than hCG and follitropin receptors 10-30% as well as hFSH, it had less than 10% and 5% the efficacies of either hormone. This suggests that complete deglycosylation will not be required to produce glycoprotein hormone analogs that have low efficacies." @default.
• W2063012807 created "2016-06-24" @default.
• W2063012807 creator A5002294450 @default.
• W2063012807 creator A5011070154 @default.
• W2063012807 creator A5044477963 @default.
• W2063012807 creator A5045480019 @default.
• W2063012807 creator A5052217265 @default.
• W2063012807 creator A5087426138 @default.
• W2063012807 date "2005-04-15" @default.
• W2063012807 modified "2023-09-26" @default.
• W2063012807 title "Crosslinked bifunctional gonadotropin analogs with reduced efficacy" @default.
• W2063012807 cites W110566743 @default.
• W2063012807 cites W1497815765 @default.
• W2063012807 cites W1500632314 @default.
• W2063012807 cites W1540088209 @default.
• W2063012807 cites W1541886985 @default.
• W2063012807 cites W1542963228 @default.
• W2063012807 cites W1552234264 @default.
• W2063012807 cites W1964034878 @default.
• W2063012807 cites W1975665188 @default.
• W2063012807 cites W1981786622 @default.
• W2063012807 cites W1986271380 @default.
• W2063012807 cites W1992872235 @default.
• W2063012807 cites W1996660028 @default.
• W2063012807 cites W1997072297 @default.
• W2063012807 cites W2008814445 @default.
• W2063012807 cites W2015162301 @default.
• W2063012807 cites W2018362378 @default.
• W2063012807 cites W2025710444 @default.
• W2063012807 cites W2028612664 @default.
• W2063012807 cites W2029699536 @default.
• W2063012807 cites W2047009435 @default.
• W2063012807 cites W2050971119 @default.
• W2063012807 cites W2063450196 @default.
• W2063012807 cites W2070060499 @default.
• W2063012807 cites W2070544534 @default.
• W2063012807 cites W2075952191 @default.
• W2063012807 cites W2092771790 @default.
• W2063012807 cites W2101417661 @default.
• W2063012807 cites W2140826535 @default.
• W2063012807 cites W2146229524 @default.
• W2063012807 cites W2171013541 @default.
• W2063012807 cites W2198261718 @default.
• W2063012807 cites W2335373775 @default.
• W2063012807 cites W2416899284 @default.
• W2063012807 doi "https://doi.org/10.1016/j.mce.2005.01.008" @default.
• W2063012807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15767043" @default.
• W2063012807 hasPublicationYear "2005" @default.
• W2063012807 type Work @default.
• W2063012807 sameAs 2063012807 @default.
• W2063012807 citedByCount "9" @default.
• W2063012807 countsByYear W20630128072014 @default.
• W2063012807 countsByYear W20630128072019 @default.
• W2063012807 crossrefType "journal-article" @default.
• W2063012807 hasAuthorship W2063012807A5002294450 @default.
• W2063012807 hasAuthorship W2063012807A5011070154 @default.
• W2063012807 hasAuthorship W2063012807A5044477963 @default.
• W2063012807 hasAuthorship W2063012807A5045480019 @default.
• W2063012807 hasAuthorship W2063012807A5052217265 @default.
• W2063012807 hasAuthorship W2063012807A5087426138 @default.
• W2063012807 hasConcept C104292427 @default.
• W2063012807 hasConcept C104317684 @default.
• W2063012807 hasConcept C108625454 @default.
• W2063012807 hasConcept C121608353 @default.
• W2063012807 hasConcept C126322002 @default.
• W2063012807 hasConcept C170493617 @default.
• W2063012807 hasConcept C185592680 @default.
• W2063012807 hasConcept C23589133 @default.
• W2063012807 hasConcept C27256138 @default.
• W2063012807 hasConcept C2777726330 @default.
• W2063012807 hasConcept C2778782382 @default.
• W2063012807 hasConcept C2781338088 @default.
• W2063012807 hasConcept C530470458 @default.
• W2063012807 hasConcept C55493867 @default.
• W2063012807 hasConcept C71240020 @default.
• W2063012807 hasConcept C71315377 @default.
• W2063012807 hasConcept C71924100 @default.
• W2063012807 hasConcept C83730767 @default.
• W2063012807 hasConceptScore W2063012807C104292427 @default.
• W2063012807 hasConceptScore W2063012807C104317684 @default.
• W2063012807 hasConceptScore W2063012807C108625454 @default.
• W2063012807 hasConceptScore W2063012807C121608353 @default.
• W2063012807 hasConceptScore W2063012807C126322002 @default.
• W2063012807 hasConceptScore W2063012807C170493617 @default.
• W2063012807 hasConceptScore W2063012807C185592680 @default.
• W2063012807 hasConceptScore W2063012807C23589133 @default.
• W2063012807 hasConceptScore W2063012807C27256138 @default.
• W2063012807 hasConceptScore W2063012807C2777726330 @default.
• W2063012807 hasConceptScore W2063012807C2778782382 @default.
• W2063012807 hasConceptScore W2063012807C2781338088 @default.
• W2063012807 hasConceptScore W2063012807C530470458 @default.
• W2063012807 hasConceptScore W2063012807C55493867 @default.
• W2063012807 hasConceptScore W2063012807C71240020 @default.
• W2063012807 hasConceptScore W2063012807C71315377 @default.
• W2063012807 hasConceptScore W2063012807C71924100 @default.
• W2063012807 hasConceptScore W2063012807C83730767 @default.
• W2063012807 hasIssue "1-2" @default.
• W2063012807 hasLocation W20630128071 @default.

• next