FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063013520> ?p ?o ?g. }

• W2063013520 endingPage "178" @default.
• W2063013520 startingPage "168" @default.
• W2063013520 abstract "Telomerase is a specialized cellular ribonucleoprotein complex that can synthesize long stretches of a DNA primer by using an intrinsic RNA template sequence. This requires that the telomerase must be able to carry out both nucleotide and repeat additions. Here, based on available structures and experimental data, a model is presented to describe these two addition activities. In the model, the forward movement of the polymerase active site along the template during the processive nucleotide addition is rectified through the incorporation of a matched base, via the Brownian ratchet mechanism. The unpairing of the DNA:RNA hybrid and then repositioning of product 3′-end after each round of repeat synthesis, which are prerequisites for the processive repeat addition, are caused by a force acting on the primer. The force results from the conformational transition of the stem III pseudoknot, which is mechanically induced by the rotation of TERT fingers together with stem IV loop towards the polymerase active site upon a nucleotide binding. Based on the model, the dynamics of processive nucleotide and repeat additions by recombinant Tetrahymena telomerase is studied analytically, which gives good quantitative explanations to the previous experimental results. Moreover, some predicted results are presented. In particular, it is shown that the repeat addition processivity is mainly determined by the difference between the free-energy change required to disrupt the DNA:RNA hybrid and that required to unfold the stem III pseudoknot. A large difference in free energy corresponds to a low repeat addition processivity while a small difference in free energy corresponds to a high repeat addition processivity." @default.
• W2063013520 created "2016-06-24" @default.
• W2063013520 creator A5026658937 @default.
• W2063013520 date "2009-09-01" @default.
• W2063013520 modified "2023-09-27" @default.
• W2063013520 title "A possible mechanism of processive nucleotide and repeat additions by the telomerase" @default.
• W2063013520 cites W1493170168 @default.
• W2063013520 cites W1548666616 @default.
• W2063013520 cites W1549476600 @default.
• W2063013520 cites W1642251103 @default.
• W2063013520 cites W1772257915 @default.
• W2063013520 cites W1964228845 @default.
• W2063013520 cites W1965130367 @default.
• W2063013520 cites W1970409098 @default.
• W2063013520 cites W1973161154 @default.
• W2063013520 cites W1973488583 @default.
• W2063013520 cites W1973711348 @default.
• W2063013520 cites W1976080580 @default.
• W2063013520 cites W1977780474 @default.
• W2063013520 cites W1987042907 @default.
• W2063013520 cites W1990517476 @default.
• W2063013520 cites W1997141870 @default.
• W2063013520 cites W2000238936 @default.
• W2063013520 cites W2004561527 @default.
• W2063013520 cites W2005786484 @default.
• W2063013520 cites W2011251205 @default.
• W2063013520 cites W2014499277 @default.
• W2063013520 cites W2015037479 @default.
• W2063013520 cites W2019802887 @default.
• W2063013520 cites W2020152372 @default.
• W2063013520 cites W2023297417 @default.
• W2063013520 cites W2024951321 @default.
• W2063013520 cites W2026856852 @default.
• W2063013520 cites W2029323559 @default.
• W2063013520 cites W2033755632 @default.
• W2063013520 cites W2035103147 @default.
• W2063013520 cites W2035953509 @default.
• W2063013520 cites W2035989575 @default.
• W2063013520 cites W2045702252 @default.
• W2063013520 cites W2052351457 @default.
• W2063013520 cites W2053620236 @default.
• W2063013520 cites W2053875211 @default.
• W2063013520 cites W2063271191 @default.
• W2063013520 cites W2069337628 @default.
• W2063013520 cites W2070507515 @default.
• W2063013520 cites W2077449437 @default.
• W2063013520 cites W2080045652 @default.
• W2063013520 cites W2083569841 @default.
• W2063013520 cites W2093321566 @default.
• W2063013520 cites W2097893279 @default.
• W2063013520 cites W2102686303 @default.
• W2063013520 cites W2110727184 @default.
• W2063013520 cites W2113368761 @default.
• W2063013520 cites W2114906350 @default.
• W2063013520 cites W2116212264 @default.
• W2063013520 cites W2122740168 @default.
• W2063013520 cites W2126535236 @default.
• W2063013520 cites W2130737471 @default.
• W2063013520 cites W2137155383 @default.
• W2063013520 cites W2138229783 @default.
• W2063013520 cites W2141964451 @default.
• W2063013520 cites W2142741915 @default.
• W2063013520 cites W2144215662 @default.
• W2063013520 cites W2145715750 @default.
• W2063013520 cites W2146739815 @default.
• W2063013520 cites W2151439223 @default.
• W2063013520 cites W2153023603 @default.
• W2063013520 cites W2164517655 @default.
• W2063013520 cites W2172149072 @default.
• W2063013520 doi "https://doi.org/10.1016/j.biosystems.2009.06.004" @default.
• W2063013520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19580845" @default.
• W2063013520 hasPublicationYear "2009" @default.
• W2063013520 type Work @default.
• W2063013520 sameAs 2063013520 @default.
• W2063013520 citedByCount "2" @default.
• W2063013520 crossrefType "journal-article" @default.
• W2063013520 hasAuthorship W2063013520A5026658937 @default.
• W2063013520 hasConcept C104317684 @default.
• W2063013520 hasConcept C105130999 @default.
• W2063013520 hasConcept C12554922 @default.
• W2063013520 hasConcept C131140672 @default.
• W2063013520 hasConcept C178790620 @default.
• W2063013520 hasConcept C185592680 @default.
• W2063013520 hasConcept C2777563447 @default.
• W2063013520 hasConcept C3017666073 @default.
• W2063013520 hasConcept C512185932 @default.
• W2063013520 hasConcept C54355233 @default.
• W2063013520 hasConcept C552990157 @default.
• W2063013520 hasConcept C70721500 @default.
• W2063013520 hasConcept C82381507 @default.
• W2063013520 hasConcept C86803240 @default.
• W2063013520 hasConcept C94581717 @default.
• W2063013520 hasConceptScore W2063013520C104317684 @default.
• W2063013520 hasConceptScore W2063013520C105130999 @default.
• W2063013520 hasConceptScore W2063013520C12554922 @default.
• W2063013520 hasConceptScore W2063013520C131140672 @default.
• W2063013520 hasConceptScore W2063013520C178790620 @default.
• W2063013520 hasConceptScore W2063013520C185592680 @default.

• next