Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063021713> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2063021713 endingPage "S85" @default.
- W2063021713 startingPage "S78" @default.
- W2063021713 abstract "This study was performed to investigate the hemodynamic properties and to analyze the effects on spectral analysis indexes (LFRR, HFRR) of autonomic control of cardiovascular function induced by administration of lercanidipine and its enantiomers in conscious, instrumented dogs. After cumulative i.v. administration, lercanidipine and its (S)-enantiomer induced dose-dependent peripheral and coronary vasodilatation. Concomitant increases in dP/dtmax and cardiac output were observed. (S)-Lercanidipine modified hemodynamic parameters, paralleling the action of the racemate at half-dose. (R)-Lercanidipine was devoid of any vasodilating action. The effects of nitrendipine on peripheral and coronary vasculature were similar to those of lercanidipine but with a lesser increase of dP/dtmax compared to lercanidipine. Both (S)-lercanidipine and lercanidipine caused a significant increase in heart rate, but only (S)-lercanidipine significantly increased LFRR. The marker of vasomotor activity LFSAP showed a mild reduction after lercanidipine, suggesting the possibility of a blunting action on vasomotor sympathetic activity. After lercanidipine infusion at a dose of 1 μg/kg/min for 15 min, total peripheral resistance and coronary resistance decreased significantly, together with a corresponding increase in coronary blood flow. After β-adrenergic blockade with propranolol, its coronary effects were slightly reduced. The time relaxation constant TAU was not modified in both conditions. Continuous infusion of lercanidipine did not modify the spectral markers LFRR and LFSAP. Pretreatment with propranolol did not significantly alter the response to lercanidipine, thus confirming the virtual absence of sympathetic activation during continuous infusion. In conclusion, lercanidipine is confirmed to be a direct and potent vasodilator calciumentry blocker with selectivity for the vascular bed." @default.
- W2063021713 created "2016-06-24" @default.
- W2063021713 creator A5001488752 @default.
- W2063021713 creator A5022249344 @default.
- W2063021713 creator A5051259646 @default.
- W2063021713 creator A5062683164 @default.
- W2063021713 creator A5089740334 @default.
- W2063021713 date "1997-01-01" @default.
- W2063021713 modified "2023-09-27" @default.
- W2063021713 title "Hemodynamic Effects and Power Spectral Analysis of Heart Rate and Arterial Pressure Variabilities Induced by Lercanidipine and Its Enantiomers in Conscious Dogs" @default.
- W2063021713 cites W2000542731 @default.
- W2063021713 cites W2030309433 @default.
- W2063021713 cites W2031745293 @default.
- W2063021713 cites W2035446448 @default.
- W2063021713 cites W2043154461 @default.
- W2063021713 cites W2049434720 @default.
- W2063021713 cites W2062618262 @default.
- W2063021713 cites W2112400936 @default.
- W2063021713 cites W2125109199 @default.
- W2063021713 cites W2430807589 @default.
- W2063021713 cites W4238337354 @default.
- W2063021713 cites W4321001158 @default.
- W2063021713 doi "https://doi.org/10.1097/00005344-199729001-00011" @default.
- W2063021713 hasPublicationYear "1997" @default.
- W2063021713 type Work @default.
- W2063021713 sameAs 2063021713 @default.
- W2063021713 citedByCount "3" @default.
- W2063021713 crossrefType "journal-article" @default.
- W2063021713 hasAuthorship W2063021713A5001488752 @default.
- W2063021713 hasAuthorship W2063021713A5022249344 @default.
- W2063021713 hasAuthorship W2063021713A5051259646 @default.
- W2063021713 hasAuthorship W2063021713A5062683164 @default.
- W2063021713 hasAuthorship W2063021713A5089740334 @default.
- W2063021713 hasBestOaLocation W20630217131 @default.
- W2063021713 hasConcept C120770815 @default.
- W2063021713 hasConcept C126322002 @default.
- W2063021713 hasConcept C164705383 @default.
- W2063021713 hasConcept C178853913 @default.
- W2063021713 hasConcept C2777953023 @default.
- W2063021713 hasConcept C2778151854 @default.
- W2063021713 hasConcept C2779283177 @default.
- W2063021713 hasConcept C2780548744 @default.
- W2063021713 hasConcept C42219234 @default.
- W2063021713 hasConcept C71924100 @default.
- W2063021713 hasConcept C84393581 @default.
- W2063021713 hasConcept C98274493 @default.
- W2063021713 hasConceptScore W2063021713C120770815 @default.
- W2063021713 hasConceptScore W2063021713C126322002 @default.
- W2063021713 hasConceptScore W2063021713C164705383 @default.
- W2063021713 hasConceptScore W2063021713C178853913 @default.
- W2063021713 hasConceptScore W2063021713C2777953023 @default.
- W2063021713 hasConceptScore W2063021713C2778151854 @default.
- W2063021713 hasConceptScore W2063021713C2779283177 @default.
- W2063021713 hasConceptScore W2063021713C2780548744 @default.
- W2063021713 hasConceptScore W2063021713C42219234 @default.
- W2063021713 hasConceptScore W2063021713C71924100 @default.
- W2063021713 hasConceptScore W2063021713C84393581 @default.
- W2063021713 hasConceptScore W2063021713C98274493 @default.
- W2063021713 hasIssue "Sup 1" @default.
- W2063021713 hasLocation W20630217131 @default.
- W2063021713 hasLocation W20630217132 @default.
- W2063021713 hasOpenAccess W2063021713 @default.
- W2063021713 hasPrimaryLocation W20630217131 @default.
- W2063021713 hasRelatedWork W1987658202 @default.
- W2063021713 hasRelatedWork W2055612716 @default.
- W2063021713 hasRelatedWork W2056841269 @default.
- W2063021713 hasRelatedWork W2151285627 @default.
- W2063021713 hasRelatedWork W2166867913 @default.
- W2063021713 hasRelatedWork W2285764257 @default.
- W2063021713 hasRelatedWork W2394584325 @default.
- W2063021713 hasRelatedWork W2418220110 @default.
- W2063021713 hasRelatedWork W2441968373 @default.
- W2063021713 hasRelatedWork W2443463695 @default.
- W2063021713 hasVolume "29" @default.
- W2063021713 isParatext "false" @default.
- W2063021713 isRetracted "false" @default.
- W2063021713 magId "2063021713" @default.
- W2063021713 workType "article" @default.