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- W2063040109 abstract "In the last several years many biologic agents for Crohn's disease have been developed. Due to their unique molecular specificity biologics are de facto indicators of the ultimate significance of the molecule targeted by the biologic itself. Here, we have reviewed many clinical studies that have used biologics for Crohn's disease. Their results show that despite potentially sound theoretical mechanisms of action and some initially promising data, most biologics – with few notable exceptions - have failed. Pharmacologic, study design or patient-related issues might explain these findings in some studies. However in many cases clinical failure of biologics might highlight the complexity of in vivo events and the potential deficiencies of current experimental settings. Hence, these observations call for new and efficient ways of predicting drug efficacy in clinical trials based on bench research. Conceivably, computer-based pathogenetic models could be used to simulate and predict clinical studies results in vivo." @default.
- W2063040109 created "2016-06-24" @default.
- W2063040109 creator A5002766726 @default.
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- W2063040109 creator A5043665456 @default.
- W2063040109 creator A5058888863 @default.
- W2063040109 creator A5091272199 @default.
- W2063040109 date "2014-01-13" @default.
- W2063040109 modified "2023-10-16" @default.
- W2063040109 title "Translational research and efficacy of biologics in Crohn's disease: a cautionary tale" @default.
- W2063040109 cites W134031355 @default.
- W2063040109 cites W1916880782 @default.
- W2063040109 cites W1964215887 @default.
- W2063040109 cites W1977912132 @default.
- W2063040109 cites W1981700839 @default.
- W2063040109 cites W1989963371 @default.
- W2063040109 cites W1990194653 @default.
- W2063040109 cites W1991688187 @default.
- W2063040109 cites W1995620440 @default.
- W2063040109 cites W1995864039 @default.
- W2063040109 cites W2000379621 @default.
- W2063040109 cites W2002883352 @default.
- W2063040109 cites W2003288227 @default.
- W2063040109 cites W2003314961 @default.
- W2063040109 cites W2005275461 @default.
- W2063040109 cites W2009025779 @default.
- W2063040109 cites W2010264478 @default.
- W2063040109 cites W2017295150 @default.
- W2063040109 cites W2021298016 @default.
- W2063040109 cites W2022253360 @default.
- W2063040109 cites W2024415920 @default.
- W2063040109 cites W2025065287 @default.
- W2063040109 cites W2025565161 @default.
- W2063040109 cites W2026679422 @default.
- W2063040109 cites W2028147079 @default.
- W2063040109 cites W2029110830 @default.
- W2063040109 cites W2029828876 @default.
- W2063040109 cites W2030638161 @default.
- W2063040109 cites W2031963525 @default.
- W2063040109 cites W2032731042 @default.
- W2063040109 cites W2033286476 @default.
- W2063040109 cites W2036242475 @default.
- W2063040109 cites W2036500213 @default.
- W2063040109 cites W2039477962 @default.
- W2063040109 cites W2041924570 @default.
- W2063040109 cites W2044229900 @default.
- W2063040109 cites W2049981804 @default.
- W2063040109 cites W2052496052 @default.
- W2063040109 cites W2053303708 @default.
- W2063040109 cites W2056558971 @default.
- W2063040109 cites W2059028043 @default.
- W2063040109 cites W2061012867 @default.
- W2063040109 cites W2066551697 @default.
- W2063040109 cites W2069921868 @default.
- W2063040109 cites W2072442610 @default.
- W2063040109 cites W2075090387 @default.
- W2063040109 cites W2077531651 @default.
- W2063040109 cites W2080087066 @default.
- W2063040109 cites W2083236656 @default.
- W2063040109 cites W2085110576 @default.
- W2063040109 cites W2085127303 @default.
- W2063040109 cites W2086404296 @default.
- W2063040109 cites W2090198994 @default.
- W2063040109 cites W2091512951 @default.
- W2063040109 cites W2097189677 @default.
- W2063040109 cites W2100832706 @default.
- W2063040109 cites W2101217991 @default.
- W2063040109 cites W2106684817 @default.
- W2063040109 cites W2108385341 @default.
- W2063040109 cites W2113591882 @default.
- W2063040109 cites W2115655620 @default.
- W2063040109 cites W2117966967 @default.
- W2063040109 cites W2118232932 @default.
- W2063040109 cites W2118877038 @default.
- W2063040109 cites W2120419234 @default.
- W2063040109 cites W2120499377 @default.
- W2063040109 cites W2121219094 @default.
- W2063040109 cites W2122516118 @default.
- W2063040109 cites W2123934318 @default.
- W2063040109 cites W2126807394 @default.
- W2063040109 cites W2128890061 @default.
- W2063040109 cites W2131131557 @default.
- W2063040109 cites W2131727319 @default.
- W2063040109 cites W2132784721 @default.
- W2063040109 cites W2134442010 @default.
- W2063040109 cites W2151734278 @default.
- W2063040109 cites W2152803022 @default.
- W2063040109 cites W2160843392 @default.
- W2063040109 cites W2164237757 @default.
- W2063040109 cites W2164861161 @default.
- W2063040109 cites W2167451347 @default.
- W2063040109 cites W4244626580 @default.
- W2063040109 cites W4251917775 @default.
- W2063040109 doi "https://doi.org/10.1586/1744666x.2014.877839" @default.
- W2063040109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24410538" @default.
- W2063040109 hasPublicationYear "2014" @default.
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