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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063048281> ?p ?o ?g. }

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• W2063048281 abstract "A series of tumor-activated prodrugs of the inhibitors of dihydropyrimidine dehydrogenase (DPD), an enzyme catabolizing 5-fluorouracil (5-FU: 4g), has been designed and synthesized. RO0094889 (11c) is a prodrug of 5-vinyluracil (4c), a known DPD inhibitor, and was designed to generate 4c selectively in tumor tissues by sequential conversion of 11c by three enzymes: esterase, cytidine deaminase and thymidine phosphorylase, the latter two of which are known to be highly expressed in various tumor tissues. When capecitabine (1), a tumor-activated prodrug of 5-FU, was co-administered orally with 11c, 5-FU in tumor tissues was significantly increased with only a slight increase of 5-FU in plasma as compared with oral capecitabine alone." @default.
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• W2063048281 date "2003-03-01" @default.
• W2063048281 modified "2023-10-16" @default.
• W2063048281 title "Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine" @default.
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• W2063048281 doi "https://doi.org/10.1016/s0960-894x(02)01082-x" @default.
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