Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063060712> ?p ?o ?g. }
- W2063060712 endingPage "5357" @default.
- W2063060712 startingPage "5348" @default.
- W2063060712 abstract "The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation. Ubiquitination of p53 is regulated by ARF, which binds to MDM2 and inhibits its E3 ligase function. P53 is also subjected to modification by conjugation of SUMO-1. We found that a p53 mutant deficient for MDM2 binding (p53(14Q19S)) is poorly sumoylated in vivo compared to wild-type p53. Overexpression of MDM2 increases the level of p53 sumoylation, which is further stimulated by expression of ARF. Stimulation of p53 sumoylation requires a highly conserved region (102-116) encoded by exon 2 of ARF and correlates with the ability of ARF to target p53 to the nucleolus. An MDM2 deletion mutant (MDM2(Delta222-437)) with activated cryptic nucleolar localization signal also targets p53 to the nucleolus and efficiently promotes p53 sumoylation in the absence of ARF. Direct targeting of p53 to the nucleolus enhances its sumoylation in an MDM2- and ARF-dependent fashion. These results show that p53 sumoylation is regulated by MDM2- and ARF-mediated nucleolar targeting." @default.
- W2063060712 created "2016-06-24" @default.
- W2063060712 creator A5014777892 @default.
- W2063060712 creator A5061568119 @default.
- W2063060712 date "2003-08-14" @default.
- W2063060712 modified "2023-09-30" @default.
- W2063060712 title "MDM2-ARF complex regulates p53 sumoylation" @default.
- W2063060712 cites W1481400971 @default.
- W2063060712 cites W1485459479 @default.
- W2063060712 cites W1491701783 @default.
- W2063060712 cites W1560780012 @default.
- W2063060712 cites W1822460389 @default.
- W2063060712 cites W1972166544 @default.
- W2063060712 cites W1983055012 @default.
- W2063060712 cites W1984405912 @default.
- W2063060712 cites W1986256428 @default.
- W2063060712 cites W1991189921 @default.
- W2063060712 cites W1995456120 @default.
- W2063060712 cites W1997388033 @default.
- W2063060712 cites W2004706142 @default.
- W2063060712 cites W2009856824 @default.
- W2063060712 cites W2012753961 @default.
- W2063060712 cites W2024894759 @default.
- W2063060712 cites W2024937228 @default.
- W2063060712 cites W2041968244 @default.
- W2063060712 cites W2049763628 @default.
- W2063060712 cites W2050259175 @default.
- W2063060712 cites W2070163476 @default.
- W2063060712 cites W2077162184 @default.
- W2063060712 cites W2079075202 @default.
- W2063060712 cites W2081667575 @default.
- W2063060712 cites W2091578636 @default.
- W2063060712 cites W2105896701 @default.
- W2063060712 cites W2116988305 @default.
- W2063060712 cites W2124595934 @default.
- W2063060712 cites W2154986076 @default.
- W2063060712 cites W2165179185 @default.
- W2063060712 doi "https://doi.org/10.1038/sj.onc.1206851" @default.
- W2063060712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12917636" @default.
- W2063060712 hasPublicationYear "2003" @default.
- W2063060712 type Work @default.
- W2063060712 sameAs 2063060712 @default.
- W2063060712 citedByCount "117" @default.
- W2063060712 countsByYear W20630607122012 @default.
- W2063060712 countsByYear W20630607122013 @default.
- W2063060712 countsByYear W20630607122014 @default.
- W2063060712 countsByYear W20630607122015 @default.
- W2063060712 countsByYear W20630607122016 @default.
- W2063060712 countsByYear W20630607122017 @default.
- W2063060712 countsByYear W20630607122018 @default.
- W2063060712 countsByYear W20630607122019 @default.
- W2063060712 countsByYear W20630607122020 @default.
- W2063060712 countsByYear W20630607122021 @default.
- W2063060712 countsByYear W20630607122022 @default.
- W2063060712 countsByYear W20630607122023 @default.
- W2063060712 crossrefType "journal-article" @default.
- W2063060712 hasAuthorship W2063060712A5014777892 @default.
- W2063060712 hasAuthorship W2063060712A5061568119 @default.
- W2063060712 hasBestOaLocation W20630607121 @default.
- W2063060712 hasConcept C104317684 @default.
- W2063060712 hasConcept C134459356 @default.
- W2063060712 hasConcept C143065580 @default.
- W2063060712 hasConcept C153911025 @default.
- W2063060712 hasConcept C171350616 @default.
- W2063060712 hasConcept C179185449 @default.
- W2063060712 hasConcept C183873130 @default.
- W2063060712 hasConcept C190062978 @default.
- W2063060712 hasConcept C25602115 @default.
- W2063060712 hasConcept C2776192174 @default.
- W2063060712 hasConcept C502942594 @default.
- W2063060712 hasConcept C54355233 @default.
- W2063060712 hasConcept C71829478 @default.
- W2063060712 hasConcept C81885089 @default.
- W2063060712 hasConcept C86803240 @default.
- W2063060712 hasConcept C95444343 @default.
- W2063060712 hasConceptScore W2063060712C104317684 @default.
- W2063060712 hasConceptScore W2063060712C134459356 @default.
- W2063060712 hasConceptScore W2063060712C143065580 @default.
- W2063060712 hasConceptScore W2063060712C153911025 @default.
- W2063060712 hasConceptScore W2063060712C171350616 @default.
- W2063060712 hasConceptScore W2063060712C179185449 @default.
- W2063060712 hasConceptScore W2063060712C183873130 @default.
- W2063060712 hasConceptScore W2063060712C190062978 @default.
- W2063060712 hasConceptScore W2063060712C25602115 @default.
- W2063060712 hasConceptScore W2063060712C2776192174 @default.
- W2063060712 hasConceptScore W2063060712C502942594 @default.
- W2063060712 hasConceptScore W2063060712C54355233 @default.
- W2063060712 hasConceptScore W2063060712C71829478 @default.
- W2063060712 hasConceptScore W2063060712C81885089 @default.
- W2063060712 hasConceptScore W2063060712C86803240 @default.
- W2063060712 hasConceptScore W2063060712C95444343 @default.
- W2063060712 hasIssue "34" @default.
- W2063060712 hasLocation W20630607121 @default.
- W2063060712 hasLocation W20630607122 @default.
- W2063060712 hasOpenAccess W2063060712 @default.
- W2063060712 hasPrimaryLocation W20630607121 @default.
- W2063060712 hasRelatedWork W1510940290 @default.
- W2063060712 hasRelatedWork W1993505588 @default.