Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063061736> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2063061736 endingPage "13" @default.
- W2063061736 startingPage "9" @default.
- W2063061736 abstract "Background We investigated the frequencies of the symptoms such as “ataxia, depression, insomnia, anorexia, and pain,” that have been reported to be associated with 5-HT1A receptor, and the effect of tandospirone citrate (tandospirone: 5-HT1A agonist) in patients with Machado-Joseph disease (MJD). Methods Ten MJD patients received tandospirone (15-30mg/d) for seven weeks. During that time, they were evaluated weekly using the Ataxia Rating Scale (ARS) and Total Length Traveled (TLT) by Stabilimetry tests, the Self-rating Depression Scale (SDS), which in addition to evaluating their level of depression, also evaluated their degree of insomnia and anorexia, and a pain questionnaire. Results Before tandospirone therapy, all patients displayed cerebellar ataxia, while insomnia, and leg pain was observed in 7 patients, depression in 6 patients, and anorexia was observed in 2 patients. In response to treatment, 7 of the 10 patients who were ataxic showed a reduction in their ARS, while 3 of 6 patients showed a reduction in their SDS, and 5 of 7 patients showed an alleviation of their insomnia and leg pain. Both of the affected patients showed a marked improvement in their anorexia. A stabilimetry test could be performed in 7 patients, 5 of whom showed a reduction in TLT. Conclusions Our data indicate that the patients with MJD are prone to manifest 5-HT1A receptor-associated symptoms, and tandospirone is a useful drug for these symptoms in patients with MJD, though a double-blind study is needed." @default.
- W2063061736 created "2016-06-24" @default.
- W2063061736 creator A5003493577 @default.
- W2063061736 creator A5007321577 @default.
- W2063061736 creator A5040454834 @default.
- W2063061736 creator A5049801477 @default.
- W2063061736 creator A5053621000 @default.
- W2063061736 creator A5054542665 @default.
- W2063061736 creator A5076101983 @default.
- W2063061736 date "2004-01-01" @default.
- W2063061736 modified "2023-10-18" @default.
- W2063061736 title "Effects of Tandospirone on “5-HT1A Receptor-Associated Symptoms” in Patients with Machado-Josephe Disease" @default.
- W2063061736 cites W1592157068 @default.
- W2063061736 cites W1968704250 @default.
- W2063061736 cites W1980263472 @default.
- W2063061736 cites W1994992939 @default.
- W2063061736 cites W2018919386 @default.
- W2063061736 cites W2021534891 @default.
- W2063061736 cites W2043288745 @default.
- W2063061736 cites W2044564499 @default.
- W2063061736 cites W2066232075 @default.
- W2063061736 cites W2067533411 @default.
- W2063061736 cites W2068480184 @default.
- W2063061736 cites W2072705316 @default.
- W2063061736 cites W2090389068 @default.
- W2063061736 cites W2091599284 @default.
- W2063061736 cites W2153486342 @default.
- W2063061736 cites W2160720083 @default.
- W2063061736 cites W2170332928 @default.
- W2063061736 doi "https://doi.org/10.1097/00002826-200401000-00005" @default.
- W2063061736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15090930" @default.
- W2063061736 hasPublicationYear "2004" @default.
- W2063061736 type Work @default.
- W2063061736 sameAs 2063061736 @default.
- W2063061736 citedByCount "30" @default.
- W2063061736 countsByYear W20630617362012 @default.
- W2063061736 countsByYear W20630617362013 @default.
- W2063061736 countsByYear W20630617362014 @default.
- W2063061736 countsByYear W20630617362018 @default.
- W2063061736 countsByYear W20630617362019 @default.
- W2063061736 countsByYear W20630617362020 @default.
- W2063061736 countsByYear W20630617362021 @default.
- W2063061736 countsByYear W20630617362022 @default.
- W2063061736 crossrefType "journal-article" @default.
- W2063061736 hasAuthorship W2063061736A5003493577 @default.
- W2063061736 hasAuthorship W2063061736A5007321577 @default.
- W2063061736 hasAuthorship W2063061736A5040454834 @default.
- W2063061736 hasAuthorship W2063061736A5049801477 @default.
- W2063061736 hasAuthorship W2063061736A5053621000 @default.
- W2063061736 hasAuthorship W2063061736A5054542665 @default.
- W2063061736 hasAuthorship W2063061736A5076101983 @default.
- W2063061736 hasConcept C118552586 @default.
- W2063061736 hasConcept C126322002 @default.
- W2063061736 hasConcept C139719470 @default.
- W2063061736 hasConcept C15744967 @default.
- W2063061736 hasConcept C162324750 @default.
- W2063061736 hasConcept C2776867660 @default.
- W2063061736 hasConcept C2778654693 @default.
- W2063061736 hasConcept C2780148635 @default.
- W2063061736 hasConcept C2780906641 @default.
- W2063061736 hasConcept C2781210498 @default.
- W2063061736 hasConcept C42219234 @default.
- W2063061736 hasConcept C71924100 @default.
- W2063061736 hasConceptScore W2063061736C118552586 @default.
- W2063061736 hasConceptScore W2063061736C126322002 @default.
- W2063061736 hasConceptScore W2063061736C139719470 @default.
- W2063061736 hasConceptScore W2063061736C15744967 @default.
- W2063061736 hasConceptScore W2063061736C162324750 @default.
- W2063061736 hasConceptScore W2063061736C2776867660 @default.
- W2063061736 hasConceptScore W2063061736C2778654693 @default.
- W2063061736 hasConceptScore W2063061736C2780148635 @default.
- W2063061736 hasConceptScore W2063061736C2780906641 @default.
- W2063061736 hasConceptScore W2063061736C2781210498 @default.
- W2063061736 hasConceptScore W2063061736C42219234 @default.
- W2063061736 hasConceptScore W2063061736C71924100 @default.
- W2063061736 hasIssue "1" @default.
- W2063061736 hasLocation W20630617361 @default.
- W2063061736 hasLocation W20630617362 @default.
- W2063061736 hasOpenAccess W2063061736 @default.
- W2063061736 hasPrimaryLocation W20630617361 @default.
- W2063061736 hasRelatedWork W2038643815 @default.
- W2063061736 hasRelatedWork W2169075874 @default.
- W2063061736 hasRelatedWork W2187620060 @default.
- W2063061736 hasRelatedWork W2485025764 @default.
- W2063061736 hasRelatedWork W2977889816 @default.
- W2063061736 hasRelatedWork W3217370556 @default.
- W2063061736 hasRelatedWork W4226044296 @default.
- W2063061736 hasRelatedWork W4293738682 @default.
- W2063061736 hasRelatedWork W4383371739 @default.
- W2063061736 hasRelatedWork W168561422 @default.
- W2063061736 hasVolume "27" @default.
- W2063061736 isParatext "false" @default.
- W2063061736 isRetracted "false" @default.
- W2063061736 magId "2063061736" @default.
- W2063061736 workType "article" @default.