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- W2063062723 abstract "Induction of c-myc gene amplification in L1210 cells by hydroxyurea and its inhibition by homoharringtonine were investigated using the DNA-DNA molecular hybridization technique. When the cells were treated with hydroxyurea 1.0 mM for 16 hours, and incubated a further 16 hours in a drug-free medium, the c-myc gene amplified 23.5-fold. If homoharringtonine 50 µM was used at the same time as hydroxyurea, gene amplification did not occur. Cycloheximide, an inhibitor of protein biosynthesis, produced a similar effect. Our results indicated that a (or some) protein factor(s) might be involved in gene amplification. Detailed analysis showed that the synthesis of this protein factor(s) started 4 hours before the initiation of the S phase but did not continue in the S phase. It was also found that this protein factor(s) was very labile and began to degrade 2 hours after its appearance." @default.
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- W2063062723 date "1989-03-01" @default.
- W2063062723 modified "2023-10-16" @default.
- W2063062723 title "Induction of C-MYC gene amplification by hydroxyurea and its inhibition by homoharringtonine" @default.
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- W2063062723 doi "https://doi.org/10.1007/bf02683532" @default.
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