FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063065143> ?p ?o ?g. }

• W2063065143 endingPage "448" @default.
• W2063065143 startingPage "441" @default.
• W2063065143 abstract "The cAMP analogue 8-Cl-cAMP induces apoptosis and inhibits proliferation of a wide variety of malignancies in vitro and in vivo with relatively little toxicity. The antitumor effects of this compound are thought to involve its ability to modulate type I protein kinase A (PKAI). However, a nontoxic metabolite of 8-Cl-cAMP, 8-Cl-adenosine, with no known activity against PKAI, exerts growth inhibitory effects in breast, ovary, pancreas, and colorectal cancer cells in vitro and accumulates in xenografted tumors after 8-Cl-cAMP treatment in vivo. To characterize further the antitumor effects of 8-Cl-adenosine in colorectal cancer, we examined its effects on cell growth in vitro (cell number, 3H-thymidine incorporation, and soft agar colony formation) using the isogenically matched colorectal cancer cell lines HCT116, HCT116-E6 (p53-depleted), and 80S14 (p21WAF1/Cip1-null). 8-Cladenosine inhibited cell growth by 89%, 74%, and 79%, respectively in HCT116, HCT116-E6, and 80S14 cells after a 72-hour exposure. Growth inhibition coincided with DNA endoreduplication and subsequent apoptosis. Furthermore, nontoxic doses of 8-Cl-adenosine administered i.p. twice weekly for 4 weeks to athymic mice suppressed growth of HCT116-derived xenografts by 50%. These results show that 8-Cl-adenosine exerts antitumor activity against colorectal cancer independent of p53 and p21WAF1/Cip1." @default.
• W2063065143 created "2016-06-24" @default.
• W2063065143 creator A5042784355 @default.
• W2063065143 creator A5063151327 @default.
• W2063065143 creator A5068642499 @default.
• W2063065143 creator A5087669330 @default.
• W2063065143 date "2000-09-01" @default.
• W2063065143 modified "2023-10-18" @default.
• W2063065143 title "8-Cl-Adenosine-Induced Inhibition of Colorectal Cancer Growth In Vitro and In Vivo" @default.
• W2063065143 cites W1509901905 @default.
• W2063065143 cites W1678957887 @default.
• W2063065143 cites W1933198004 @default.
• W2063065143 cites W1979319210 @default.
• W2063065143 cites W1982097971 @default.
• W2063065143 cites W2008117987 @default.
• W2063065143 cites W2037615996 @default.
• W2063065143 cites W2041302882 @default.
• W2063065143 cites W2042316019 @default.
• W2063065143 cites W2099682050 @default.
• W2063065143 cites W2119411170 @default.
• W2063065143 cites W2127422069 @default.
• W2063065143 cites W2130544215 @default.
• W2063065143 cites W2140631531 @default.
• W2063065143 cites W2416461245 @default.
• W2063065143 cites W2602544133 @default.
• W2063065143 cites W3151029295 @default.
• W2063065143 doi "https://doi.org/10.1038/sj.neo.7900106" @default.
• W2063065143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1507978" @default.
• W2063065143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11191111" @default.
• W2063065143 hasPublicationYear "2000" @default.
• W2063065143 type Work @default.
• W2063065143 sameAs 2063065143 @default.
• W2063065143 citedByCount "22" @default.
• W2063065143 countsByYear W20630651432012 @default.
• W2063065143 countsByYear W20630651432013 @default.
• W2063065143 countsByYear W20630651432014 @default.
• W2063065143 countsByYear W20630651432015 @default.
• W2063065143 countsByYear W20630651432019 @default.
• W2063065143 countsByYear W20630651432022 @default.
• W2063065143 crossrefType "journal-article" @default.
• W2063065143 hasAuthorship W2063065143A5042784355 @default.
• W2063065143 hasAuthorship W2063065143A5063151327 @default.
• W2063065143 hasAuthorship W2063065143A5068642499 @default.
• W2063065143 hasAuthorship W2063065143A5087669330 @default.
• W2063065143 hasBestOaLocation W20630651431 @default.
• W2063065143 hasConcept C121608353 @default.
• W2063065143 hasConcept C126322002 @default.
• W2063065143 hasConcept C134018914 @default.
• W2063065143 hasConcept C150903083 @default.
• W2063065143 hasConcept C153911025 @default.
• W2063065143 hasConcept C190283241 @default.
• W2063065143 hasConcept C202751555 @default.
• W2063065143 hasConcept C207001950 @default.
• W2063065143 hasConcept C2776991684 @default.
• W2063065143 hasConcept C2779707156 @default.
• W2063065143 hasConcept C502942594 @default.
• W2063065143 hasConcept C526805850 @default.
• W2063065143 hasConcept C55493867 @default.
• W2063065143 hasConcept C62112901 @default.
• W2063065143 hasConcept C71924100 @default.
• W2063065143 hasConcept C86803240 @default.
• W2063065143 hasConcept C98274493 @default.
• W2063065143 hasConceptScore W2063065143C121608353 @default.
• W2063065143 hasConceptScore W2063065143C126322002 @default.
• W2063065143 hasConceptScore W2063065143C134018914 @default.
• W2063065143 hasConceptScore W2063065143C150903083 @default.
• W2063065143 hasConceptScore W2063065143C153911025 @default.
• W2063065143 hasConceptScore W2063065143C190283241 @default.
• W2063065143 hasConceptScore W2063065143C202751555 @default.
• W2063065143 hasConceptScore W2063065143C207001950 @default.
• W2063065143 hasConceptScore W2063065143C2776991684 @default.
• W2063065143 hasConceptScore W2063065143C2779707156 @default.
• W2063065143 hasConceptScore W2063065143C502942594 @default.
• W2063065143 hasConceptScore W2063065143C526805850 @default.
• W2063065143 hasConceptScore W2063065143C55493867 @default.
• W2063065143 hasConceptScore W2063065143C62112901 @default.
• W2063065143 hasConceptScore W2063065143C71924100 @default.
• W2063065143 hasConceptScore W2063065143C86803240 @default.
• W2063065143 hasConceptScore W2063065143C98274493 @default.
• W2063065143 hasIssue "5" @default.
• W2063065143 hasLocation W20630651431 @default.
• W2063065143 hasLocation W20630651432 @default.
• W2063065143 hasLocation W20630651433 @default.
• W2063065143 hasLocation W20630651434 @default.
• W2063065143 hasOpenAccess W2063065143 @default.
• W2063065143 hasPrimaryLocation W20630651431 @default.
• W2063065143 hasRelatedWork W1965943749 @default.
• W2063065143 hasRelatedWork W1978639835 @default.
• W2063065143 hasRelatedWork W2026105695 @default.
• W2063065143 hasRelatedWork W2031470785 @default.
• W2063065143 hasRelatedWork W2056270585 @default.
• W2063065143 hasRelatedWork W2074641809 @default.
• W2063065143 hasRelatedWork W2130981205 @default.
• W2063065143 hasRelatedWork W2320914227 @default.
• W2063065143 hasRelatedWork W2398262967 @default.
• W2063065143 hasRelatedWork W2905993336 @default.
• W2063065143 hasVolume "2" @default.
• W2063065143 isParatext "false" @default.

• next